Coagulation Disorders

Question 0

Extrinsic pathway (clotting factor)

Answer 0

PT

V, VII, X, PT, fibrogen

Question 1

Intrinsic pathway (clotting factors)

Answer 1

PTT
V, VIII, IX, X, XI
XII, PT, fibrogen

Question 2

Aspirin (MOA)

Answer 2

Inhibits platelet activation

Question 3

Aspirin: toxic dose

         Lethal dose

Answer 3

150mg/kg

500mg/kg

*uncoupler of oxidative phosphorylation

Question 4

Samter triad of aspirin toxicity

Answer 4

Asthma
Aspirin sensitivity
Nasal polyps

Question 5

DOC for prevention of retstenosis in PCI

Answer 5

Abciximab, Eptifibatide, Tirofiban

Antiplatelet: GPIIb/IIIa inhibitor

Question 6

MOA Clopidogrel, ticlopidine, prasugel

Answer 6

ADP inhibitor

Question 7

PDE III inhibitor

Answer 7

Dipyridamole, Cilostazol

Thromboembolic prophylaxis

Question 8

Antiplatelet vs anticoagulant

Answer 8

Arterial vs. venous

Question 9

Indirect thrombin inhibitors

Answer 9

Heparin, enoxaparin, LMWH

PTT (activates antithrombin III)

Antidote: Protamine

Question 10

Direct thrombin inhibitors

Answer 10

Warfarin

PT (II, VII,IX, X)

Antidote: Vit K, FFP

Question 11

Anticoagulant overlap

Answer 11

To bypass initial prothrombic effect of warfarin (antithrombin effect after 8-60 hrs after administration)

Question 12

t-PA analog

Answer 12

Streptokinase, altaplase

Antidote: aminocalproic acid/tranexamic acid

Question 13

DOC for hemophilia A and Von Willebrand dse

Answer 13

Desmopressin