Histamine, Serotonin And Ergot Alkaloids

Question 0

Excess production of histamine detected by

Answer 0

Imidazole acetic acid in urine

Question 1

Precursor of histamine

Answer 1

Histidine

E: monoamine oxidase and diamine oxidase

Question 2

Triple response

Answer 2

Wheal, flush, flare

Question 3

Histamine:smooth muscle

Answer 3

H1

Ant: diphenhydramine

Question 4

Histamine: stomach, heart, mast cell

Answer 4

H2

Ant: cemitidine

Question 5

H1 blocker

Answer 5

Diphenhydramine, chlorpheniramine, cyclizine, promethazine

SE: drowsiness, dry mouth, ortho static hypotension

Question 6

2nd gen H1 blocker

Answer 6

Ceterizine, loratidine

SE:fatal arrhythmia with azoles

Question 7

Happy hormone

Answer 7

Serotonin

Question 8

Serotonin: Vomiting/antagonist

Answer 8

5-HT3/ondansetron

Question 9

Serotonin: Smooth muscles, platelets

Answer 9

5-HT2

Question 10

Serotonin: brain

Answer 10

5HT1D

Question 11

Serotonin: migraine

5HT1D agonist

Answer 11

Sumatriptan, zolmitriptan

Question 12

____ produced by fungus in wet or spoiled grain/St. Anthony’s fire
Partial agonist at a-adrenoreceptors and 5-HT receptors

Answer 12

Ergot alkaloids

Question 13

Vasoselective Ergot alkaloid (5-HT2 receptor antagonist)

Answer 13

Ergotamine

DOC for Migraine, cluster headache

SE: uterine spasm, GI upset, vasospasm
Antidote: nitroprusside

Question 14

Ergot Alkaloid: Uteroselective (5-HT2 receptor antagonist)

Answer 14

Ergonovine, methylergonovine

DOC: postpartum bleeding, migraine

Abortifacient