NSAIDs Flashcards
What are the three main functions of NSAIDs?
Anti-pyretic
Anti-inflammatory
Analgesic
What are NSAIDs method of action?
They inhibit inflammatory mediators called COX 2
Which is present in most tissues? COX enzyme 1 or COX enzyme 2
COX1
What cytokine induces COX 2?
IL-1
What is prostaglandin?
They are inflammatory mediators
Which NSAID causes lung allergies?
Aspirin
What is a common side effect of NSAIDS on the GI?
Ulcers
What is substrate diversion?
By inhibiting the COX enzyme, the reaction to produce prostaglandins so there are more substrates to make other products (leukotrienes)
What do leukotrienes do?
They activate an allergic response
Why are NSAIDs dangerous in people with kidney problems?
The kidney contains prostaglandins, so inhibiting COX 2 would decrease amount of prostaglandins and so reduce kidney function
Why do NSAIDS cause GI ulcers?
COX 1 Prostaglandins produce cytoprotective which protects the gut wall from the acid inside. By inhibiting COX1, the acid can damage the gut
What are coxibs?
Selective COX2 inhibitor drugs
Why are coxibs only used in patients with high risk of ulcer?
They have high cvs risk, MI/stroke
Which COX does aspirin inhibit?
COX1
What does aspirin do?
Reduces thromboxane production and therefore reduces platelet production
