Coagulation

Question 1

What does tissue factor induce?

Answer 1

Prothrombin to thrombin

Question 2

What does thrombin mediate?

Answer 2

Fibrinogen to fibrin

Question 3

What two things are needed for haemostasis?

Answer 3

Von Willebrand Factor

Collagen

Question 4

What does vitamin K do?

Answer 4

It is a procoagulant

Question 5

Which drug stimulates VWF release in haemostasis?

Answer 5

Desmopressin

Question 6

What blocks fibrin degradation?

Answer 6

Tranexamic acid

Question 7

What are venous thrombi high in?

Answer 7

Fibrin

Question 8

What are arterial thrombi high in?

Answer 8

Platelets

Question 9

What are the three aspects of Virchows triad?

Answer 9

Abnormal blood flow
Blood vessel damage
Hypercoagubility

Question 10

How do anticoagulants act as antithrombosis drugs?

Answer 10

Limit thrombin production (factor 11a)

Question 11

Name three anticoagulants

Answer 11

Warfarin
Heparin
Rivaroxiban/ apixaban

Question 12

What does Aspirin inhibit?

Answer 12

Cox1

Question 13

Name anti-platelet drugs

Answer 13

Clopidogrel
Prasugrel
Vorapaxar
Aspirin

Question 14

How do fibrinolytic drugs work?

Answer 14

Degrade fibrin (clot busters)

Question 15

What kind of drugs are streptokinase and alteplase?

Answer 15

Fibrinolytic

Question 16

What drug would you use in stroke?

Answer 16

Alteplase

Question 17

Which type of fat mops up cholesterol?

Answer 17

HDLs

Question 18

How do statins work?

Answer 18

Inhibit cholesterol formation

Question 19

What kind of drugs are atorvastatin and simvastatin?

Answer 19

Statins

Question 20

How do fibrates work?

Answer 20

Induces lipoprotein lipases

Question 21

How do niacin drugs work?

Answer 21

Decrease VLDL production in liver

Question 22

What kind of drug is Acipimax?

Answer 22

Niacin