Coagulation Flashcards
What does tissue factor induce?
Prothrombin to thrombin
What does thrombin mediate?
Fibrinogen to fibrin
What two things are needed for haemostasis?
Von Willebrand Factor
Collagen
What does vitamin K do?
It is a procoagulant
Which drug stimulates VWF release in haemostasis?
Desmopressin
What blocks fibrin degradation?
Tranexamic acid
What are venous thrombi high in?
Fibrin
What are arterial thrombi high in?
Platelets
What are the three aspects of Virchows triad?
Abnormal blood flow
Blood vessel damage
Hypercoagubility
How do anticoagulants act as antithrombosis drugs?
Limit thrombin production (factor 11a)
Name three anticoagulants
Warfarin
Heparin
Rivaroxiban/ apixaban
What does Aspirin inhibit?
Cox1
Name anti-platelet drugs
Clopidogrel
Prasugrel
Vorapaxar
Aspirin
How do fibrinolytic drugs work?
Degrade fibrin (clot busters)
What kind of drugs are streptokinase and alteplase?
Fibrinolytic
What drug would you use in stroke?
Alteplase
Which type of fat mops up cholesterol?
HDLs
How do statins work?
Inhibit cholesterol formation
What kind of drugs are atorvastatin and simvastatin?
Statins
How do fibrates work?
Induces lipoprotein lipases
How do niacin drugs work?
Decrease VLDL production in liver
What kind of drug is Acipimax?
Niacin
