NSAIDs Flashcards
What are some indications of use for NSAIDs?
Mild chronic pain and peri-surgical pain
T/F: NSAIDs are shorter acting than opioids but not as good analgesic
FALSE. NSAIDs are longer acting
What receptors do NSAIDs act on?
PGE2 and PGI2-inhibition of mediators of inflammation and pain
What is an anti-pyretic?
Inhibition of endotoxin or endogenous pyrogen
What is the difference of the MOA of NSAIDs and Steroids?
NSAIDs: act by inhibiting COX receptors
Steroids: act by inhibiting phospholipase, preventing formation of arachdonic acid from cell membrane phospholipids
Which COX receptor is constitutive and which is inducible.
COX-1: constitutive
COX-2: inducible
Aspirin, ketoprofen, phenylbutazone, flunixine meglumine are what type of NSAID?
Nonselective COX inhibitors
Meloxicam, carprofen, etodolac are what type of NSAID?
Preferential COX-2 inhibitors-weak COX-1 inhibitors
Robenacoxib, Firocoxib, Deracoxib are what type of NSAIDs?
Selective COX-2 inhibitor
Why are NSAIDs contraindicated with pregnant patients?
COX-2 is necessary for nephrogenesis
What age can pediatric patients begin getting NSAIDs?
When they are 4-weeks or older. Nephrogenesis isn’t completed until 3-weeks of age
T/F: COX-2 is essential for fracture healing. Use NSAIDs at low doses for short periods.
TRUE
What species is predisposed to NSAID toxicity?
Cats-slow clearance and dose-dependent elimination. Longer T 1/2
What is the name of the oral/injectable NSAID that can be given for 3 day span.
Robenacoxib-onsior (COX-2 Selective Inhibitor)
What NSAID has oral and injectable forms that is a COX-2 preferential inhibitor?
Carprofen
