NSAIDS Flashcards
Carprofen selectivity
No COX-1:COX-2 selectivity in clinical use
Carprofen used in what species
Only dogs, avoid in cats
Carprofen problems
- GI, renal, hepatic
- higher incidence in Labs
- wash out period before switch to any other NSAID
Ketoprofen selectivity
Has little to no COX-1:COX-2 selectivity
Ketoprofen approved in
Horses (non food), and dogs and cats.
-injectable only
Complications with ketoprofen
- GI (dogs)
- GI/renal (horses)
Deracoxib class of inhibitors
Coxib
Deracoxib selectivity
Highly selective for COX 2 enzymes
Deracoxib used in:
Dogs (post op pain)
Deracoxib contraindicated in:
Dogs with sulfonamide sensitivity
Flunixin Medglumine selectivity
No COX 1 or COX 2 selectivity
Flunixin megalumine used in
Horses, swine, cattle
- dogs are sensitive to GI damage
Flunixin megalumine is limited by
Toxicity (<5 days)
Flunixin megalumine available as:
Injectable form for IV/IM or a metered paste
flunixin megalumine used for
Muscle pain, inflammation, pyrexia, colic, post op pain from de horning
Flunixin megalumine withdrawal time (dairy cattle, beef, veal,swine)
- 36h
- 4 days
- NOT VEAL
- 12d
Phenylbutazone used in
Horses mainly but also dogs
Phenylbutazone selectivity
Little Cox1/cox2 selectivity
Phenylbutazone exhibits good ____ actions
Analgesic and antipyretic
Phenylbutazone can’t be given by:
IM
Can phenylbutazone be given to food animals
NOO
Tepoxalin is a member of what class
Dual-acting agents which inhibit both CoX1 and cox2 as well as LOX
-all actions occur at clinical doses
Topeoxalin inhibits formation of:
PGs, Txs, leukotrienes
Topeoxalin approved for use in:
Dogs
