NSAIDS

Question 1

What are the roles of NSAIDS?

Answer 1

Supresses signs and symptoms of inflammation
Exerts anti-pyretic and analgesic effects
Inhibits COX and prostaglandin synthesis (anti-inflammatory)

Question 2

What would inhibition of COX and prostaglandin synthesis lead to?

Answer 2

Numerous adverse reactions such as:
GIT
Cardiovascular
Renal Problems

Question 3

What is the pH of NSAIDs?

Answer 3

Weak organic acids

Question 4

What is the only NSAID that is not a weak organic acid?

Answer 4

Nabumetone

Question 5

What is the rate of absorption of NSAIDs?

Answer 5

Rapid

Question 6

What is the only NSAID that is poorly absorbed?

Answer 6

Ketorolac

Question 7

What are the dosage forms of Ketorolac?

Answer 7

Parenteral, Topical

Question 8

What are the effects of food on NSAID’s Absorption?

Answer 8

Food delays absorption and decreases bioavailability

Question 9

What two NSAIDs are good examples of decreased absorption when taken with food?

Answer 9

Fenoprofen

Sulindac

Question 10

How long will it take for the NSAIDs to reach peak plasma levels?

Answer 10

2-3 hours

Question 11

How long will it take Etoricoxib to reach peak plasma level?

Answer 11

1 hour

Question 12

What percentage of NSAIDs are protein bound?

Answer 12

95-99%

Question 13

If displaced from proteins, what will happen to the effect of these NSAIDs?

Answer 13

It will increase in presence of other drugs

Question 14

After repeated dosing, where will NSAIDs be usually found?

Answer 14

Synovial Fluid

Question 15

What is the relationship between the amount of time the NSAIDs remaining in joints and their half lives?

Answer 15

Inverse