NSAIDs

Question 1

NSAIDs are supposed to _______

Answer 1

Inhibit Cox enzymes & bad prostaglandins

Question 2

Which type of drug has Anti-Platelet use? Aspirin, tNSAIDs, Acetaminohen, Celecoxib

Answer 2

Aspirin.

None of the others are anti-platelet

Question 3

Which drug is not an Anti-inflammatory? Aspirin, tNSAIDs, Acetaminohen, Celecoxib

Answer 3

Acetaminophen

Question 4

Which drug has no side effects on stomach, platelet, kidney, uterus, or clotting in vessels?

Answer 4

Acetaminophen

Question 5

Which drug has a pro clotting side effect?

Answer 5

Celecoxib

Question 6

COX1 in platelets makes…

Answer 6

Thromboxane

Question 7

COX2 in platelets makes…

Answer 7

Prostacyclin

Question 8

What are the actions of COX2?

Answer 8

Development
Inflamation
Reproductive
Tissue Repair
Fever
Renal Fxn
Pain

DIRT is FRee of Pain

Question 9

What are the actions of COX1?

Answer 9

GI protection
Platelet Aggregation
Renal Fxn

Question 10

How do tNSAIDs work in terms of COX1/2 action?

Answer 10

Inhibit COX1/2 and reversible

Question 11

How does Celecoxib work in terms of COX1/2 action?

Answer 11

Reversible Inihbition of COX2

Question 12

How does acetaminophen work in terms of COX1/2 action?

Answer 12

Reversible inhibition of CNS COX2

Question 13

How does aspirin work in terms of COX1/2 action?

Answer 13

Irreversible inhibition of COX1/2

Low dose is selective for COX 1

Question 14

Increased bleeding risk occurs in side effects of COX _____ Inhibitors in _______ cells

Answer 14

COX 1 in Platelets

Question 15

Increased clotting events occurs in side effects of COX _____ Inhibitors in ________ cells.

Answer 15

COX 2 in endothelial cells

Question 16

What are the contraindications of tNSAIDs?

Answer 16

1. Old people
2. Stomach ulcers
3. Concurant glucocorticoid use

Question 17

Which drug and concentration is the COX1 selective inhibitor?

Answer 17

Low Dose Aspirin

Question 18

Which tNSAID is best for patients with GI problems?

Answer 18

Ibuprofen

Inhibits COX2 more than COX1

GI-Ibuprofen

Question 19

Which tNSAID is best for patients with Cardiovascular problems?

Answer 19

Naproxen

Inhibits COX1 more than COX 2

“Cross my heart” NaproXen has a cross (X) and goes with CV problems

Question 20

Which drug doesn’t decrease kidney function?

Answer 20

Acetaminophen because it ONLY inhibits COX2 in the CNS.

Question 21

Who would be a good candidate for Celecoxib?

Answer 21

People who cant tolerate high doses of NSAIDs due to GI problems but need anti-inflammatory effects.

NOT FOR PATIENTS WITH CV PROBLEMS

Question 22

How do you treat Aceaminophen OD?

Answer 22

N-acetylcystine

Question 23

Why is aspirin OD unique? How do you treat it?

Answer 23

Originally presents as respiratory alkalosis. Later it is a metabolic acidosis.
Treat with a gastric lavage and NaHCO3.

Question 24

What are prostacyclin’s effect on vascular smooth muscle and platelets?

Answer 24

Vasodilation and anti-clotting

Question 25

What are thromboxane A2’s effect on vascular smooth muscle and platelets?

Answer 25

Vasoconstriction and Pro clotting

Question 26

Describe the effects of leukotrienes on inflammatory cell function and pulmonary/vascular smooth muscle.

Answer 26

1. Neutrophil Chemotaxis, aggregation and transmigration (LTB4)
2. Inc Vascular Perm, Bronchoconstriction, vasoconstriction. Think of allergies. (LTC4 LTD4 LTE4 )