NSAIDs Flashcards
COX 1 OR 2
Which do we want to function and which is considered a side effect?
Cox 1 is side effect, cox2 is induced
COX 1 OR 2
Which one is more active in homeostasis?
Cox 1
Elderly is effected by side effects of COX 1 OR 2
inhibitors
Dyspepsia Bleeding & Hemorrhage skin reactions renal insufficiency nephropathy bronchospasm hyperkalemia liver/bone marrow suppression
COX 2 blocks cause what effects
antipyretic
analgesia
anti-inflamatory
Salicylic acids (names)
Aspirin
Diflunisal
Acetic acids (names)
Ketorolac
Indomethacin
Nabumetone
Propionic acid (names)
Ibuprofen
Naproxin
Diarylheterocyclics
Celecoxib
Rofecoxib
Aspirin is…
Irreversible COX i.
Half life 2-4h
Aspirin: adverse effects:
/O2 use
sensitivity to aspirin: asthma sinusitis or urticaria.
reye syndrome
/clotting time
Diflunisal effects
use for inflammation
longer than aspirin
not in CNS as well
less GI effects
Tylenol effects
use for pain and fever
not good for inflammation
Ibuprofen
delay birth
increased MI risk
Naproxen uses
limit 10days gout bursitis tendonitis dysmenorrhea pain spondylitis arthritis
Indomethacin
most potent
PDA closure
Many unapproved FDA uses
