GI

Question 1

Omeprazole (prilosec)

Answer 1

Prodrug
(PPI) H-ATP inhibitor
3+hrs for effectiveness

Question 2

NaBicarb

Answer 2

Fast

Na may not be good for heart disease

Question 3

MgHydroxide

Answer 3

Fast

Mg=Laxative

Question 4

CaCarbonate

Answer 4

Fast
Cause Metabolic alkalosis
Gassy

Question 5

Aluminum Hydroxide

Answer 5

Fast
Al=Constipation
Low Phos levels

Question 6

Metoclopramide (Reglan)

Answer 6

Increases lower esophageal tone
Accelerates clearance
Reverses Opiate constipation

Question 7

Sucralfate

Answer 7

Requires Low pH for activation

Question 8

Phenothiazines-(Compazine)

Answer 8

Anti-emetic

Blocks Dopamine chemoreceptor receptor trigger zone

Question 9

Serotonin- Ondansetron (Zofran)

Answer 9

Anti-emetic

Chemotherapy single dose - H/A & diarrhea

Question 10

Droperidol (Droleptan)

Answer 10

Dopamine Chemoreceptor trigger zone
Depresses CNS
Depresses CV

Question 11

Corticosteroids- Dexamethasone (Decadron)

Answer 11

Anti-emetic
Blocks prostaglandins
Increases sugar

Question 12

Cannabinoids- Dronabinol (Marinol), Nabilone (Cesamet)

Answer 12

Anti-emetic

Dysphoria, Hallucinations, Sedations, Vertigo, Disorientation

Question 13

Substance P/ Neurokinin 1

Aprepitant (emend)

Answer 13

Anti-emetic
give with steroid
Constipation and fatigue

Question 14

Diphenoxylate (Lomotil)

Loperamide (Imodium)

Answer 14

Anti-diarrheal
Stop AcH from contraction
Doesn’t cross BBB

Question 15

Chenodiol, Ursodiol (Actigall, Urso)

Answer 15

Gall stones

Dissolves floating stones (small ones)

Question 16

Mild Crohns disease Tx

Answer 16

Budesonide (ileitis)
Topical steroids
Antibiotics
5-Aminosalicylates

Question 17

Moderate Crohns Tx

Answer 17

TNF Antagonists
Oral Steroids
Methotrexate
Azathioprine/ 6-Mercaptopurine

Question 18

Severe Crohns Tx

Answer 18

Surgery
Natalizumab
Cyclosporine
TNF Antagonists
IV steroids

Question 19

Steroids - uses

Answer 19

inflammatory cytoines

Moderate to severe IBD

Question 20

5-Aminosalicyclic Acid

Answer 20

Mild-Moderate
Inhibits icytokines
Sulfasalazine has the most sideeffects

Question 21

Puring Analogs (azathioprine, Mercaptopurine)

Answer 21

immunosuppressive
maintenance of remission
SE: N/V, Bone marrow depression

Question 22

Methotrexate

Answer 22

Inhibition of dihydrofolate reductase

Question 23

TNF Alpha Antibodies

Answer 23

Binds TNF Alpha- which fights infections

SE: Infections!