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SRNA Pharmacology Exam 3 > GI > Flashcards

GI Flashcards

1
Q

Omeprazole (prilosec)

A

Prodrug
(PPI) H-ATP inhibitor
3+hrs for effectiveness

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2
Q

NaBicarb

A

Fast

Na may not be good for heart disease

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3
Q

MgHydroxide

A

Fast

Mg=Laxative

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4
Q

CaCarbonate

A

Fast
Cause Metabolic alkalosis
Gassy

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5
Q

Aluminum Hydroxide

A

Fast
Al=Constipation
Low Phos levels

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6
Q

Metoclopramide (Reglan)

A

Increases lower esophageal tone
Accelerates clearance
Reverses Opiate constipation

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7
Q

Sucralfate

A

Requires Low pH for activation

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8
Q

Phenothiazines-(Compazine)

A

Anti-emetic

Blocks Dopamine chemoreceptor receptor trigger zone

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9
Q

Serotonin- Ondansetron (Zofran)

A

Anti-emetic

Chemotherapy single dose - H/A & diarrhea

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10
Q

Droperidol (Droleptan)

A

Dopamine Chemoreceptor trigger zone
Depresses CNS
Depresses CV

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11
Q

Corticosteroids- Dexamethasone (Decadron)

A

Anti-emetic
Blocks prostaglandins
Increases sugar

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12
Q

Cannabinoids- Dronabinol (Marinol), Nabilone (Cesamet)

A

Anti-emetic

Dysphoria, Hallucinations, Sedations, Vertigo, Disorientation

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13
Q

Substance P/ Neurokinin 1

Aprepitant (emend)

A

Anti-emetic
give with steroid
Constipation and fatigue

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14
Q

Diphenoxylate (Lomotil)

Loperamide (Imodium)

A

Anti-diarrheal
Stop AcH from contraction
Doesn’t cross BBB

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15
Q

Chenodiol, Ursodiol (Actigall, Urso)

A

Gall stones

Dissolves floating stones (small ones)

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16
Q

Mild Crohns disease Tx

A

Budesonide (ileitis)
Topical steroids
Antibiotics
5-Aminosalicylates

17
Q

Moderate Crohns Tx

A

TNF Antagonists
Oral Steroids
Methotrexate
Azathioprine/ 6-Mercaptopurine

18
Q

Severe Crohns Tx

A 
Surgery
Natalizumab
Cyclosporine
TNF Antagonists
IV steroids
19
Q

Steroids - uses

A

inflammatory cytoines

Moderate to severe IBD

20
Q

5-Aminosalicyclic Acid

A

Mild-Moderate
Inhibits icytokines
Sulfasalazine has the most sideeffects

21
Q

Puring Analogs (azathioprine, Mercaptopurine)

A

immunosuppressive
maintenance of remission
SE: N/V, Bone marrow depression

22
Q

Methotrexate

A

Inhibition of dihydrofolate reductase

23
Q

TNF Alpha Antibodies

A

Binds TNF Alpha- which fights infections

SE: Infections!

SRNA Pharmacology Exam 3 (6 decks)

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