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SRNA Pharmacology Exam 3 > Histamine > Flashcards

Histamine Flashcards

1
Q

Histamine has what 2 compounds?

A

Amine

Imidazole

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2
Q

Mast cells

A

major histamine container,

Color change:BluetoRed

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3
Q

Two types of Mast Cell Categories

A

Connective tissue

Mucosal tissue

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4
Q

Mucosal tissue mast cells are stimulated by:

A

Interleukins

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5
Q

In the blood, where is most histamine found

A

Basophilic Leukocytes

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6
Q

What is slow turnover histamine release?

A

Mast cell histamine is slowly released

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7
Q

What is rapid release histamine?

A

Found in neurons,
vascular endothelium,
endocrine-like cells (stomach).
These are resistant to histamine releasing Rx.

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8
Q

What mediates or inhibits histamine release?

A

Macrophages,

Platelets.

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9
Q

Histamine made from what molecule & what is known to “induce” histamine?

A

L-histidine,
L-histidine decarboxylase,
histamine

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10
Q

What two pathways breakdown histamine?

A

Oxidation

Methylation

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11
Q

What is Skin Triple response

A

small red spot from dilation,
large flare from vasodilation of nerves,
wheal from edema.

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12
Q

What therapeutic uses for histamine?

A

NONE

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13
Q

Effects(receptor) of Histamine on Man?

A 
Vasodilation H1,
Gastric acid H2,
Bronchospasm H1,
Vomit/Diarrhea H1,
/HR H2.
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14
Q

What use is H3?

A

Sleep,
Dementia,
Obesity.

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15
Q

What use is H4?

A

Anti-inflammatory

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16
Q

Non-immunological reaction & examples

A

Narcotics, contrast, NMB.

Does not require Ca or energy to produce histamine release and reaction.

17
Q

Immunological reactions & examples

A

Histamine released by IgE cells binding to mast cells. They must see the antigen twice for the second time reaction.

18
Q

Steps to “specific” immunologic release of histamine

A

be sensitized by first exposure,
second exposure activates IgEs,
release of Ca,
much more than just histamine is released by mast cells so the effects of activation is more than just from histamine

SRNA Pharmacology Exam 3 (6 decks)

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