Anti-Histamine Flashcards

1
Q

What are the clinically useful H1 blockers (1st gen.)? (5)

A
Diphenhydramine
Tripelennamine
Chlorpheniramine
Cyclizine
Promethazine
(brain penetrating)
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2
Q

Weird therapeutic uses of H1 blockers

A

Meniere’s syndrome (inner ear disturbance)
Parkinsons
Topical local anesthetic
Urticaria (skin rash)

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3
Q

What does H1 blocker overdose look like and treatment?

A

atropine-like effects

Treat with support, no antidote available.

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4
Q

3 ways that 1st and 2nd gen H1 blockers are different?

A

1 dose per day
No BBB penetration
Lack Anticholinergic/serotonin effects

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5
Q

H2 blockers (4)

A

Cimetidine
Ranitidine
Famotidine
Nizatidine

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6
Q

Clinical usefulness of H2 blockers

A

Systemic Mastocytosis
Ulcers
GERD
Acid Aspiration

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7
Q

When is the body stressed for H2 blocker use in hospitals?

A
Trauma
Burn
resp failure
Shock
Sepsis
Stroke
Surgery
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8
Q

What H2 blocker interferes with liver enzyme and which one, What Rx do you need to watch for?

A

Cimetidine
P450
Warfarin
Theophyline

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9
Q

Anti-Release Agents

What do they do or would they ideally do?

A

stabilize mast cells (200+) compounds.

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10
Q

What are Anti-Release Agents used for?

A

Asthma prevention (in kids)
Rhinitis
Eyes
Powder (for lungs)

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