Anti-Histamine Flashcards
What are the clinically useful H1 blockers (1st gen.)? (5)
Diphenhydramine Tripelennamine Chlorpheniramine Cyclizine Promethazine (brain penetrating)
Weird therapeutic uses of H1 blockers
Meniere’s syndrome (inner ear disturbance)
Parkinsons
Topical local anesthetic
Urticaria (skin rash)
What does H1 blocker overdose look like and treatment?
atropine-like effects
Treat with support, no antidote available.
3 ways that 1st and 2nd gen H1 blockers are different?
1 dose per day
No BBB penetration
Lack Anticholinergic/serotonin effects
H2 blockers (4)
Cimetidine
Ranitidine
Famotidine
Nizatidine
Clinical usefulness of H2 blockers
Systemic Mastocytosis
Ulcers
GERD
Acid Aspiration
When is the body stressed for H2 blocker use in hospitals?
Trauma Burn resp failure Shock Sepsis Stroke Surgery
What H2 blocker interferes with liver enzyme and which one, What Rx do you need to watch for?
Cimetidine
P450
Warfarin
Theophyline
Anti-Release Agents
What do they do or would they ideally do?
stabilize mast cells (200+) compounds.
What are Anti-Release Agents used for?
Asthma prevention (in kids)
Rhinitis
Eyes
Powder (for lungs)