NSAIDs 2 Flashcards
NSAID medications
Ibuprofen Naproxen Indomethacin Aspirin Celecoxib Meloxicam Diclofenac Trolamine salicylate
NSAID indications
analgesia antipyretic anti-inflammatory
Aspirin indications
analgesia antipyretic anti-inflammatory antithrombotic
NSAID MOA
reversibly inhibits COX-1 and COX-2 enzymes to decrease prostaglandin formation
how is Aspirin’s MOA different from other NSAIDS?
it irreversibly binds to COX enzymes, other NSAIDs reversibly bind
general NSAID’s AE
N/V, dyspepsia, ulcers, GI bleeding, increased BP, nephrotoxicity, CV risk
Rare Aspirin AE
skin rash, bleed and bruising,
photosensitivity,
bronchospams,
Raye Syndrome in Children
NSAIDs common routes
PO
topical
IM
IV
Aspirin common routes
PO rectal
what NSAIDs are antithrombotic?
Aspirin
Celecoxib
Diclofenac
Trolamine Salicylate
Meloxicam
If you have GI risk which NSAID is the safest to take?
Ibuprofen (motrin, Advil)
If you are at CV risk what is the safest NSAID to take?
Naproxen
When should you avoid taking Celecoxib?
If you are at CV risk
If you hae CV risk what NSAID should you avoid?
Celexocib
If you have CV risk which NSAID is safest to take?
Naproxen
If you have GI risk which NSAIDs are safe for you to take?
Celecoxib, Ibuprofen
NSAIDs administered by what route give the lowest dose and for the shortest duration?
Topical
T/F: someone with CHF shouldn’t take NSAIDs because it will increase their fluid retention
TRUE
T/F: NSAIDs blunt the action of cardiovascular drugs?
TRUE
If a patient is taking Ibuprofen, what should you watch out for?
Elderly, poor kidney function, history of GI bleed, any CV issues
