DMARDs 2

Question 1

what else is methotrexate indicated for?

Answer 1

lupus

Question 2

Hydroxychloroquine trade name

Answer 2

Plaquenil

Question 3

Other indications for hydroxychloroquine?

Answer 3

lupus malaria

Question 4

What DMARDs are indicated for lupus?

Answer 4

methotrexate hydroxychloroquine

Question 5

DMARDs common routes

Answer 5

PO, IV, sub cutan

Question 6

which DMARDs have only the PO route?

Answer 6

methotrexate, sulfasalazine hydroxychloroquine

Question 7

which DMARDs are administered IV, or sub cut?

Answer 7

Adalimumab, etanercept rituximab

Question 8

methotrexate common AE

Answer 8

N/V/D, alopecia, malaise

Question 9

methotrexate less common AE

Answer 9

increased liver function tests, heptatoxicity, nephrotoxicity, thrombocytopenia, bone marrow suppression

Question 10

sulfasalazine AE

Answer 10

Nausea, rash, hepatitis, pneumonitis, bone marrow suppression

Question 11

hydroxychloroquine AE

Answer 11

dyspepsia, nausea, abdominal pain, rashes, nightmares and visual disturbances

Question 12

rituximab AE

Answer 12

injection/infusion reactions, increased LFTs, antibody development

Question 13

DMARD (biologic TNF Inh) common AE

Answer 13

headache, infection, antibody development, IV infusion reactions (fever, hypotension, urticaria)

Question 14

DMARD (biologic TNF In) Boxed warnings

Answer 14

serious infections, secondary malignancies like lymphoma

Question 15

what are the three subtypes of DMARDs?

Answer 15

Non-biologic, Biologic (TNF/Non-TNF inhibitor)

Question 16

What 3 drugs are Non-biologic DMARDs?

Answer 16

Methotrexate, Sulfasalazine, Hydroxychloroquine

Question 17

What 2 drugs are TNF Inhibitors?

Answer 17

Adalimumab, Etanercept

Question 18

What drug is a Non-TNF inhibitor?

Answer 18

Rituximab

Question 19

How are biologic DMARDs usually administered?

Answer 19

IV, subcut.

Question 20

How are Non-biologic DMARDs usually administered?

Answer 20

PO

Question 21

What is the basic MOA for DMARDs?

Answer 21

impacts mediators of inflammatory response

Question 22

What is the MOA of Methrotrexate?

Answer 22

unknown, but possibly impacts IL-1, TNF-alpha, leukotreine levels

Question 23

AE of hydroxychloroquine

Answer 23

nightmares, visual disturbances, GI (N, dyspepsia), skin rash

Question 24

which DMARDs have boxed warnings?

Answer 24

Adalimumab, Etanercept

Question 25

AE TNF inhibitors

Answer 25

headache, antibody development, infection, IV reactions

Question 26

common AE Methotrexate

Answer 26

N/V/D, malaise, alopecia,

Question 27

AE Rituximab

Answer 27

increased LFTs, antibody development, injection infusion reaction

Question 28

rare AE Methotrexate

Answer 28

hepatotoxicity, nephrotoxicity, thrombocytopenia, bone marrow suppression

Question 29

MTX PT concerns

Answer 29

hydration, photo-sensitivity, caution: strengthening, stretching, deep tissue work, infection risk