DMARDs

Question 1

DMARD drug list

Answer 1

Methotrexate, Sulfasalazine, Adalimumab, Etanercept, Rituximab Hydroxyhloroquine

Question 2

Non-biologic DMARDs

Answer 2

Methotrexate, Sulfasalazine Hydroxychloroquine

Question 3

DMARD (biologic TNF Inhibitor)

Answer 3

Adalimumab, Etanercept

Question 4

DMARD (biologic Non-TNF Inhibitor)

Answer 4

Rituximab

Question 5

Adalimumab trade name

Answer 5

Humira

Question 6

Etanercept trade

Answer 6

Enbrel

Question 7

Rituximab trade name

Answer 7

Rituxan

Question 8

DMARD indications

Answer 8

RA

Question 9

what else is methotrexate indicated for?

Answer 9

lupus

Question 10

Hydroxychloroquine Drug Class

Answer 10

DMARD (non-biologic) antimalarial

Question 11

Hydroxychloroquine trade name

Answer 11

Plaquenil

Question 12

Other indications for hydroxychloroquine?

Answer 12

lupus malaria

Question 13

What DMARDs are indicated for lupus?

Answer 13

methotrexate hydroxychloroquine

Question 14

DMARDs common routes

Answer 14

PO, IV, sub cutan

Question 15

which DMARDs have only the PO route?

Answer 15

methotrexate, sulfasalazine hydroxychloroquine

Question 16

which DMARDs are administered IV, or sub cut?

Answer 16

Adalimumab, etanercept rituximab

Question 17

sulfasalazine and hydroxychloroquine MOA

Answer 17

impacts mediators of inflammatory response

Question 18

methotrexate MOA

Answer 18

possibly impacting IL-1, TNF-alpha, and leukotriene levels

Question 19

DMARD biologic TNF inhibitor MOA

Answer 19

bind TNF-alpha receptors to modulate downstream effects on inflammatory processes

Question 20

Rituximab MOA

Answer 20

basic MOA impacts inflammation process

Question 21

methotrexate common AE

Answer 21

N/V/D, alopecia, malaise

Question 22

methotrexate less common AE

Answer 22

increased liver function tests, heptatoxicity, nephrotoxicity, thrombocytopenia, bone marrow suppression

Question 23

sulfasalazine AE

Answer 23

Nausea, rash, hepatitis, pneumonitis, bone marrow suppression

Question 24

hydroxychloroquine AE

Answer 24

dyspepsia, nausea, abdominal pain, rashes, nightmares and visual disturbances

Question 25

rituximab AE

Answer 25

injection/infusion reactions, increased LFTs, antibody development

Question 26

DMARD (biologic TNF Inh) common AE

Answer 26

headache, infection, antibody development, IV infusion reactions (fever, hypotension, urticaria)

Question 27

DMARD (biologic TNF In) Boxed warnings

Answer 27

serious infections, secondary malignancies like lymphoma

Question 28

what are the three subtypes of DMARDs?

Answer 28

Non-biologic, Biologic (TNF/Non-TNF inhibitor)

Question 29

What 3 drugs are Non-biologic DMARDs?

Answer 29

Methotrexate, Sulfasalazine, Hydroxychloroquine

Question 30

What 2 drugs are TNF Inhibitors?

Answer 30

Adalimumab, Etanercept

Question 31

What drug is a Non-TNF inhibitor?

Answer 31

Tituximab

Question 32

How are biologic DMARDs usually administered?

Answer 32

IV, subcut.

Question 33

How are Non-biologic DMARDs usually administered?

Answer 33

PO

Question 34

What is the basic MOA for DMARDs?

Answer 34

impacts mediators of inflammatory response

Question 35

What is the MOA of Methrotrexate?

Answer 35

unknown, but possibly impacts IL-1, TNF-alpha, leukotreine levels

Question 36

AE of hydroxychloroquine

Answer 36

nightmares, visual disturbances, GI (N, dyspepsia), skin rash

Question 37

which DMARDs have boxed warnings?

Answer 37

Adalimumab, Etanercept

Question 38

AE TNF inhibitors

Answer 38

headache, antibody development, infection, IV reactions

Question 39

common AE Methotrexate

Answer 39

N/V/D, malaise, alopecia,

Question 40

AE Rituximab

Answer 40

increased LFTs, antibody development, injection infusion reaction

Question 41

rare AE Methotrexate

Answer 41

hepatotoxicity, nephrotoxicity, thrombocytopenia, bone marrow suppression

Question 42

MTX PT concerns

Answer 42

hydration, photo-sensitivity, caution: strengthening, stretching, deep tissue work, infection risk