NSAIDs 1

Question 1

NSAIDs - MOA

Answer 1

Inhibition of prostaglandin synthesis by cyclooxygenase (COX) inhibition

Question 2

NSAIDs - cautions & contraindications

Answer 2

Severe salicylate hypersensitivity
Double NSIAD treatment
2nd half of pregnancy

Question 3

NSAIDs - general adverse effects

Answer 3

GI ulcers & bleeding.
Renal & hepatic dysfunction.
Lithium toxicity & hyperkalemia.

Question 4

NSAIDs - interactions

Answer 4

Inh excretion of lithium, aminoglycosides & methotrexate.
Interfere with diuretics, betablockers, angiotensin inhibitors.
Hyperkalemia with potassium-sparing diuretics

Question 5

Nonselective COX-inhibitors (13 drugs)

Answer 5

Aspirin, ibuprofen, ketoprofen, naproxen, acetaminophen, indomethacin, sulindac, ketorlac, piroxicam, nabumetone, etodolac, meloxicam, diclofenac

Question 6

Aspirin - indications

Answer 6

MI prophylaxis, thromboembolic disorders

Question 7

Aspirin - MOA

Answer 7

Irreversible inhibition of COX in platelets

Question 8

Salicylates - adverse effects

Answer 8

Reye syndrome (in children with viral disease)

Question 9

Salicylates - interactions

Answer 9

Alter effect of antidiabetic drugs.

Question 10

Ibuprofen can be combined with H2 antagonist to treat?

Answer 10

Rheumatoid arthritis

Osteoarthritis

Question 11

NSAID used in long term treatment

Answer 11

Naproxen

Question 12

COX3 inhibitor (1 drug)

Answer 12

Acetaminophen

Question 13

Acetaminophen - adverse effects

Answer 13

Hepatic necrosis
Renal dysfunction (long-term use)
But fewer GI problems

Question 14

Which NSAID can be used in children with viral infection?

Answer 14

Acetaminophen

Question 15

Which NSAID is safe in pregnancy?

Answer 15

Acetaminophen