DMARDs 2

Question 1

Immunomodulators (3 groups)

Answer 1

TNF-α antagonists
IL-1 antagonist
Anti-IL-6 antibody

Question 2

TNF-α blockers (5 drugs)

Answer 2

Etanercept
Infliximab
Adalimumab
Certolizumab
Golimumab

Question 3

TNF-α blockers - adverse effects

Answer 3

Serious infections & sepsis
Opportunistic infections
Lymphomas

Question 4

Etanercept - MOA

Answer 4

Soluble TNFα receptors with Fc fragments of IgG1 that antagonize TNFα.

Question 5

Etanerecpt - indications

Answer 5

Alternative treatment for RA (often with methotrexate)

Question 6

TNFα-blocker that inactivates TNFα

Answer 6

Infliximab

Question 7

Which DMARD is also indicated for Chron disease?

Answer 7

Infliximab

Question 8

TNFα blocker with sustained activity

Answer 8

Certolizumab

Question 9

Can TNFα blockers be combined with methotrexate?

Answer 9

yaaas

Question 10

IL-1 antagonist

Answer 10

Anakinra

Question 11

Anakinra - adverse effects

Answer 11

Serious infections

Lymphomas

Question 12

Immunomodulator indicated for juvenile idiopathic arthritis

Answer 12

Tocilizumab

Question 13

Tocilizumab - MOA

Answer 13

Selective binding to IL-6 receptors, inhibiting IL-6 activity

Question 14

Sulfasalazine - contraindication

Answer 14

Sulfa-allergy