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30 NSAIDS, DMARDs, gout > Gout > Flashcards

Gout Flashcards

1
Q

Preventing gout attacks (3 groups)

A

Uricosuric drugs
Xanthine oxidase inhibitors
Catabolic enzyme preparations

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2
Q

Uricosuric drugs (2 drugs)

A

Probenecid

Sulfinpyrazole

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3
Q

Uricosuric drugs - indications

A

Under-excretion of uric acid

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4
Q

Probenecid - MOA

A

Increases excretion of uric acid by competitive inhibition of uric acid reabsorption

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5
Q

Sulfinpyrazole - MOA

A

Complete inhibition of urate reabsorption, increasing uric acid excretion

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6
Q

Xanthine oxidase inhibitors (2 drugs)

A

Allopurinol

Febuxostat

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7
Q

Xanthine oxidase inhibitors - indications

A

Overproduction of uric acid

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8
Q

Allopurinol - indications

A

Hyperuricemia & gout in cancer patients with high purine catabolism

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9
Q

Which xanthine oxidase inhibitor has greatest efficacy?

A

Febuxostat

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10
Q

Catabolic enzyme preparations (2 drugs)

A

Pegloticase

Rasburicase

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11
Q

Pegloticase - indications

A

Refractory chronic gout

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12
Q

Pegloticase - adverse effects

A

Life-threatening allergic reactions

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13
Q

Rasburicase - indications

A

ONLY: initial management of plasma uric acid in pediatric and adults with leukemia, lymphoma & solid tumor malignancies

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14
Q

Drugs for treating gout (2 drugs)

A

Indomethacin (/other NSAIDs)

Clochicine

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15
Q

Indomethacin - indications

A

Acute gout

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30 NSAIDS, DMARDs, gout (5 decks)

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