november 14

Question 1

fates of cholesterol after synthesis

Answer 1

in vertebrates most of it is syntehsized in the liver then exported as bile acids, biliary cholesterol, cholesteryl esters, or lipoproteins

Question 2

physical properties of cholesterol

Answer 2

cholesterol and phospholipids are amphipathic. have reasonable solubility in water and significant proportion o their structures prefers not to be in water

Question 3

physical properties of triacylglycerols

Answer 3

hydrophobic

Question 4

how are phspholipds, triglycerides, cholesterol, and cholesterol esters move in the body through circulation

Answer 4

packaged with proteins into hydrophilic macromolecule complex called a lipoprotein- spherical particles

Question 5

what is the surface of the lipoprotein made of

Answer 5

apolipoprotein and a phospholipid monolayer

Question 6

what does the interior of lipoproteins contain

Answer 6

cholesterol, TAGs, and cholesterol esters

Question 7

what are the four major classes of lipoprotein particles

Answer 7

cholymicrons, VLDL, LDL, HDL

Question 8

which are the largest but lightest class of lipoprotein particles

Answer 8

cholymicrons, contain the most triacylglycerols

Question 9

deliver triglycerides from the intestines that are dellivered from food intake

Answer 9

chylomicrons

Question 10

deliver triglycerides derived from the liver to non hepatic tissues

Answer 10

VLDL

Question 11

deliver cholesterol and cholesteryl esters derived from the liver to non hepatic tissues

Answer 11

removes excess cholesterol from non hepatic tissues

Question 12

apolipoprotein

Answer 12

protein without lipid but can associate with lipid

Question 13

what refers tot he protein part of a lipoprotein particle

Answer 13

apolipoprotein

Question 14

apo B28 and ApoB100 connection to lipoprotein

Answer 14

they are non exchangabel, they never fall off of a lipoprotein
all other apos can fall off and are exchangeable

Question 15

where is apo b 48 generated

Answer 15

in the intestine thorugh the enzymatic removal of an amine group from a specific cytidine on the mRNA sequence for apo B100 to generate uracil

this introduces a stop codon 48% into the spo B100 mRNA sequence

Question 16

the major protein component of HDL

Answer 16

apoA-I

Question 17

what are the functions of ApoA-I

Answer 17

maintaining the structure of HDL, interacting with lipid transporters (ABCA1) and activating lecithin; cholesterol acyltransferase (LCAT)

Question 18

what is lecitin=

Answer 18

phosphatidylcholine (PC)