extra Flashcards
what makes subsequent steps more thermodynamically favourable
making malonyl coa
what in ACP is useful
vitamin B5 derivative that contains SH group
where do we get DHAP for TAG synth
glycolysis
gluconeogenesis
glyceroneogenesis
glycerol kinase is where
liver and kideny
removal of phosphate gorup on phosphatidic acid
phoasphatidci acid phosphotase
precursor of TAG
phosphotidic acid
what does phosphotidic acid phosphotase yield
1,2 diacylglycerol
what cells dont have glycerol kinase
adipose cells
where does glyceroneogenesis occur
liver and adipose tissue
head groups of phospholipids
serine, H, choline, ethanolamine, inisitol, glycerol
what functions to store FA, and signallnig molecules iwthin cells
phospholipids
what do VLDLs do
deliver TAG from liver to non hepatic tissue
what does LDL do
delivers cholesterol AND CHOLESTEROL ESTERS from liver to non hepatic tissue
functions for cholesterol transport/ clearance
apoB48
binds to LDL receptors
APOB100
where is apo B48 generated
in the intestine
what is fromed by A1 or A2
lysophospholipid
what is removed by A2 in mammals
arachidonic acid (20:4n-6) form sn2
what cells express LDL receptors
adipose and muscle
what happens to cholesterol from HDL in liver
metabolized
where is LPL
anchored to cell surfaces of tissues exxposed to circulation
what does LPL do
hydrolyzes triglycerides containing 48 and 100
genetic disorders
LPL deficiency
LDL receptor defect
RCT ulitimate action
ultimately for excretion from the body
cholesterol efflux
transfer of cholesterol and phospholipids to nascnet HDL
cholesterol ester to cholesterol enzyme
CHOLESTEROL ESTER HYDROLASE
what do omega 3 FA do
inc cholesterol efflulx
reduce sdLDL!!!!!!!!!!!!!!
where do bile acids work
in the interstine
bile salts
conjugated bile acids such as taurine and glycine
where are bile acids formed and stored
formed in liver and stored in galbladder
what increases excretion fo bile acids
bile acid binding agents
multifactorila features of atheroschlerosis
lipid disorder
hypertensive disorder
inflamatory disorder
what is atheroschlerosis
excess deposition of lipids (TAG and cholesterol) in macrophages in arterial walls
what are monocytes attracted to
oxidized liporoteins that aggregate and stick to extracellular matrix
what happesn after foam celll ingests lipoprotein
free C accumulate in membranes and droplets
cholesterol rich plaques form
what causes formation of sdLDL
high LDL
excress hydrolysis
oxLDL
LDL protein AND lipid are oxidized
what down regulates cholesterol synth
PUFA
do PUFAs do
down regular cholesterol synth
inhibit CETP
riase HDL
