notes Flashcards
what is the therapeutic effect of immunomodulation?
immunpotentiation, immunosupression and induction of immunological tolerance
what are NK cells?
they are cellular components of the innate immune system
what is SCID?
sever combined immunodeficiency - paediatric emergency due to the lack of or defects of critical T cell molecules - cured by haemopoietic stem cell transplant
what is an allergic reaction?
it is a damaged, undesired, discomfort producing and sometimes fatal reaction produced by the normal immune system against innocuous antigens in a pres senitised host
what are the characteristics of the innate immunity?
it is short lived, quick response with no memory
what is Anti?-TNF?
it was the first biological to be used in the treatment of RA and can also be used in other inflammatory conditions such as Crohns, ankylosing spondylitis, psoriasis but can increase the risk of TB
what is the atopic triad?
it is a triad consisting of a skin condition, an allergic condition and a nasopharyngeal condition called allergic rhinitis that results in nasal congestion with oedema, mucus and nasal polyps
what can HLA typing be used for?
can be used to reduce rejection episodes and increase the chances of graft survival - serologically or molecule
what are the tuberculin test and the poison ivy test examples of ?
it is a delayed type of hypersensitivity reaction - IV - granulomas are seen on histology
what is autoinflammation?
it is a process where there are seemingly spontaneous attacks of systemic inflammation with no demonstrable source of infection as precipitating cause which causes an absence of high titre autoantibodies and antigen specific autoreactive T cells and no evidence of autoantigenic exposure
what is HLA in context of organ transplantation?
human leukocyte antigen
how many types of rejection are antibody mediated?
2 - the other type is cell mediated
what happens 7-10 days after transplant in some cell mediated cases?
T cell dependent immune process where the transplanted tissue may lose function - acute cellular rejection
where commonly are clinical manifestations of allergic reaction to food seen?
the respiratory tract, GIT and skin
what is autoimmunity?
the process where the adaptive immune system recognises the bodys own molecules, cells and tissues instead of infectious agents and malignant cells
