Normal Erythropoesis

Question 1

What are red blood cells produced from?

Answer 1

pluripotent stem cells

Question 2

What removes fragile old RBCs from circulation?

Answer 2

spleen

Question 3

What does iron bind to in the blood to be recycled?

Answer 3

transferrin

Question 4

What shape are mature erythrocytes?

Answer 4

biconcave discs

Question 5

Do red blood cells have a mitochondria?

Answer 5

no

Question 6

What type of glycolysis occurs to enable ATP synthesis?

Answer 6

anaerobic (due to lack of mitochondria

Question 7

NADH keeps iron in what state?

Answer 7

Fe2+

Question 8

What is required for glutathione?

Answer 8

NADPH

Question 9

When is 2BPG produced?

Answer 9

when there is low oxygen

Question 10

Do allosteric interactions follow Michaelis-Menten kinetics?

Answer 10

no

Question 11

Describe the shape of the curve of substrate concentration against reaction speed?

Answer 11

sigmoidal

Question 12

What does this describe: the influence that the binding of a ligand to one site on the molecule has on the binding of ligand to a different functional site

Answer 12

cooperativity

Question 13

What has a higher affinity for O2, foetal or adult Hb, and why?

Answer 13

foetal Hb - This facilitates the transfer of O2 from the mother to the foetus