Bleeding Disorders

Question 1

Give an example of a vascular acquired primary haemostatic problem?

Answer 1

Henoch-Schonlein Purpura

Question 2

One cause of failure of platelet formation (primary haemostasis) is reduced platelet function. Give some acquired causes of this.

Answer 2

drugs e.g. aspirin/NSAIDs

Renal failure

Question 3

Thrombocytopenia can be caused by destruction of platelets or failure or production. Give 3 causes of Destruction of platelets (acquired).

Answer 3

Coagulopathy e.g. Disseminated intravascular coagulation
Autoimmune e.g. Immune thrombocytopenic purpura (ITP)
Hypersplenism

Question 4

What is the pattern of inheritance for hereditary VwF deficiency?

Answer 4

autosomal dominant

Question 5

What is the commonest cause of primary haemostatic failure?

Answer 5

thrombocytopenia (usually acquired)

Question 6

Does Disseminated Intravascular Coagulation tend to be hereditary or acquired?

Answer 6

acquired

Question 7

Is haemophilia hereditary or acquired?

Answer 7

hereditary

Question 8

What two bleeding disorder problems are caused by disseminated intravascular coagulation?

Answer 8

primary, due to destruction of platelets (thrombocytopenia)

Secondary, due to multiple clotting factor deficiency

Question 9

How is haemophilia inherited?

Answer 9

x linked

Question 10

What are the two types of haemophilia?

Answer 10

A - problem with factor VIII

B - problem with factor IX

Question 11

Which is the more common haemophilia type?

Answer 11

A (5 times more common)

Question 12

How does liver failure cause failure of formation of a fibrin clot?

Answer 12

reduced coagulation factor synthesis