Iron in Health Flashcards
1
Q
Where does the Fe2+ ion sit?
A
in the porphyrin ring
2
Q
Where would a biopsy be taken if needed in:
- iron deficiency
- iron overload
A
bone marrow for deficient
liver for overload
3
Q
What is the major negative regulator of iron uptake?
A
Hepcidin
4
Q
How do mucosal factors regulate iron uptake?
A
DMT-1 (divalent metal transporter) at mucosal surface
Ferroportin at serosal surface
5
Q
What Down-regulates ferroportin?
A
hepcidin
6
Q
What Facilitates iron export from the enterocyte?
A
ferroportin
7
Q
What Transports iron into the duodenal enterocyte?
A
DMT-1
8
Q
The following are features of what: Arthritits Cirrhosis Diabetes Cardiomyopathy Weakness/fatigue Joint pains Impotence?
A
hereditary haemochromotosis
9
Q
Treatment of hereditary haemochromatosis?
A
Weekly phlebotomy
10
Q
Why is family screening so important in haemochromotosis?
A
Haemochromatosis may be asymptomatic until irreversible organ damage has occurred
