Noradrenaline (FS Week 5)

Question 1

What is a catecholamine neurotransmitter

Answer 1

is a monoamine neurotransmitter

Question 2

How is noradrenaline synthesised

Answer 2

synthesised from tyrosine
tyrosine > DOPA > Dopamine > Noradrenaline > adrenaline

levels of tyrosine hydroxylase is regulated by noradrenaline levels

Question 3

How is noradrenaline stored

Answer 3

stored in vesicles by VMAT2 to protect it from degradation

Question 4

What is a consequence of NT degradation

Answer 4

behavioural changes

Question 5

What are the noradrenergic receptors

Answer 5

a1 (a,b,c,d) - Gq coupled
a2(a,b,c,d) - Gi coupled
B(1,2,3) - Gs coupled

Question 6

How is noradrenaline degraded

Answer 6

the degradation reaction is catalysed by the enzymes

• catechol-O-methyltransferase
• monoamine oxidase

Question 7

What is the main metabolite of noradrenaline degradation that can be measure in urine

Answer 7

MHPG

(methoxy-4-hydroxyphenylglycol)

Question 8

Where do the main noradrenergic pathways originate from

Answer 8

the locus coerulus in the cerebellum

Question 9

What are two roles of noradrenaline in the CNS

Answer 9

• arousal
• consolidation of emotional memories