Neuropeptides and Endogenous Opioids (FS Week 3) Flashcards
Where are neuropeptides synthesised
in the neuronal cell body in the rough endoplasmic reticulum and golgi apparatus
Why are neuropeptides good drug targets
they are neuromodulators
can neuropeptides cross the blood brain barrier
no
What is the difference between neuropeptides and neurotransmitters
NP - slow acting - produce prolonged action
NT - fast acting - produce short term effects
Name 4 opioid receptors
- MOP
- KOP
- DOP
- NOP
Opioid receptors are what kind if GPCRs - describe the mechanism of action
Gi
inhibitory
K+ channel opening is increased which causes hyperpolarization.
there is a decrease in Ca2+ channels opening
this results in reduced neuronal excitability and reduces NT release.
Inhibits adenylyl cyclase and CAMP, PKA
How do opioids modulate pain
they activate the PAG which stimulates the descending inhibitory neurons to modulate pain
How do opioids stimulate reward and pleasure region of the brain
They increase the secretion of dopamine from the nucleus accumbens
How do opioids regulate reward when their receptors are stimulated on a GABAergic interneuron
GABA has an inhibitory action - opioids bind and inhibit the release of GABA this causes an increase in dopamine secretion
Endorphins induce reward by acting on which opioid receptor
U opioid receptors
What is the name of the opioid that inhibits dopamine release
Dynorphin by acting on KOP receptor
Why can drugs of abuse become addictive in relation to opioids
they induce the release of endogenous opioids
Which opioid acts on MOP and DOP receptors
B-endorphins
Which opioid acts on DOP receptors
Enkephalin
which opioid acts on KOP receptors
Dynorphin
