Nonselective Beta blockers

Question 1

partial beta antagonists used in the presence of a full agonist act as

Answer 1

antagonists

Question 2

inverse agonists

Answer 2

metoprolol and betaxolol

Question 3

beta blockers

Answer 3

reduce blood pressure

reduce renin release from kidney

Question 4

blockage of B2 in skeletal muscle blood vessels

Answer 4

inhibits relaxation –> increased peripheral vascular resistance INITIALLY. returns to normal

Question 5

pheochromocytoma (increased epi) + beta blocker

Answer 5

requires ADDITION OF AN ALPHA BLOCKER

Question 6

respiratory effects of blocking B2

Answer 6

bronchoconstriction

Question 7

avoid beta blockers in

Answer 7

patients with asthma, COPD

Question 8

you have to give a beta blocker (even topically for glaucoma) to a patient with asthma, which are the best options?

Answer 8

B1 selective blockers (atenolol, metoprolol) or drugs with intrinsic sympathetic activity

Question 9

glaucoma is treated with beta blockers because

Answer 9

they reduce intraocular pressure by decreasing production of aqueous humor. DOC

Question 10

blocks both B1 and B2 receptors, often used to treat glaucoma

Answer 10

timololol

Question 11

better glaucoma tx in asthmatics as its B1 selective

Answer 11

betaxolol

Question 12

normally, decreased glycogenolysis and gluconeogenesis by beta blockers is easily reversed by

Answer 12

glucagon response

Question 13

beta blockers can cause hypoglycemia in T1DM because

Answer 13

glucagon response is impaired and hypoglycemia symptoms are masked

Question 14

T1DM who needs a beta blocker should receive _______ because ______

Answer 14

B1 selective blocker

blockage of glycogenolysis is mediated by B2 receptors

Question 15

bad lipid effects with beta blockers

Answer 15

due to inhibition of lipolysis by blocking B3 receptors
more specific (B1, intrinsic activity) will cause less

Question 16

contraindicated beta blockers for glaucoma

Answer 16

have local anesthetic activity –> anesthetize cornea, increasing likelihood of scratches

Question 17

local anesthetic activity of beta blockers is mediated by

Answer 17

membrane stabilizing action through blockage of sodium channels

Question 18

beta blockers with local anesthetic activity

Answer 18

PPALM
Pindolol
Propranolol
Acebutolol
Labetolol
Metoprolol

Question 19

propranolol acts on

Answer 19

B1 and B2

Question 20

drug which may suppress ventricular arrhythmias

Answer 20

propranolol

Question 21

side effects of propranolol

Answer 21

gets into CNS –> sedation, depression

Question 22

propranolol metabolism is decreased by

Answer 22

liver disease

Question 23

propranolol uses for CV system

Answer 23

1. decreased BP
2. decreased mortality from MI/CHF
3. treat angina
4. treat arrhythmia
5. treat obstructive cardiomyopathy

Question 24

other random propranolol uses

Answer 24

1. prevent migraine
2. hyperthyroidism (causes tachycardia)
3. reduce tremor, stage fright
4. reduce risk of bleeding in patients with cirrhosis

Question 25

usually beta blockers help CHF mortality, but in these situations could killa ya

Answer 25

late stage CHF
MI
cardiomegaly

Question 26

abrupt discontinuation of beta blockers can cause

Answer 26

cardiac arrhythmia due to up regulation of B receptors

Question 27

drugs that inhibit the metabolism of propranolol

Answer 27

cimetidine

chlopromazine

Question 28

drugs that increase the metabolism of propranolol

will make it less effective

Answer 28

barbiturates
phenytoin
rifampin
smoking

Question 29

beta blocker who’s systemic use won’t cause sedation bc it doesn’t enter CNS

Answer 29

nadolol

also okay for glaucoma

Question 30

beta blocker which blocks potassium channels and has antiarrhythmic activity

Answer 30

sotalol