Adrenergic stimulants general info

Question 1

tyrosine is _____ to become l dopa

Answer 1

hydroxylated

Question 2

l dopa is ______ to dopamine

Answer 2

decarboxylated

Question 3

DA is _______ to form NE in noradrenergic neurons synaptic vesicles

Answer 3

hydroxylated

Question 4

rate limiting pathway of DA/NE/Epi production

Answer 4

conversion of tyrosine to l dopa (hydroxylation which occurs in cytoplasm of presynaptic knob)

Question 5

NE is converted to epi in the

Answer 5

adrenal medulla

Question 6

drugs that cause release of NE from the presynaptic terminal

Answer 6

tyramine
amphetamine
only have effect if the noradrenergic innervation is intact

Question 7

a patient comes in with severe denervation and you want to provide them with sympathetic stimulation. what class of drugs aren’t going to work?

Answer 7

indirect adrenergic stimulants

Question 8

action of NE is terminated by

Answer 8

reuptake

Question 9

drugs which block NE reuptake

Answer 9

cocaine, antidepressants

Question 10

MAO hangs out _________ and breaks down NE that’s _______

Answer 10

outer surface of mitochondria

released in the presynaptic terminal

Question 11

MAO

Answer 11

monamine oxidase

Question 12

COMT

Answer 12

catechol O methyl transferase

Question 13

measure these in 24 hour urine to evaluate NE/Epi metabolism

Answer 13

VMA and HVA

Question 14

VMA

Answer 14

3 methoxy 4 hydroxy mandelic aci

Question 15

HVA

Answer 15

homovanillic acid

Question 16

relaxation of blood vessels supplying skeletal muscle

Answer 16

B2

Question 17

relaxation of smooth muscle in gut and bronchial tree

Answer 17

B2

Question 18

increase rate and contractility of the heart

Answer 18

B1 B2

Question 19

increase glycogenolysis in liver/muscle, lipolysis from adipose cells

Answer 19

B2 B3

Question 20

3 indirect adrenergic stimulant MOAs

Answer 20

1. increase release of NE from nerve endings
2. inhibit reuptake of NE
3. inhibit metabolism of NE

Question 21

depletion of NE stores would mean that

Answer 21

indirect adrenergic stimulants can’t work

Question 22

denervation has _________ on direct acting adrenergic stimulants

Answer 22

no effect or enhances effect (receptors are up regulated, super sensitive)

Question 23

contraction of the prostate gland

Answer 23

a1

Question 24

stimulate pilomotor smooth muscle causing erection of hair

Answer 24

a1

Question 25

Cause aggregation of platelets

Answer 25

a2

Question 26

Decrease insulin secretions

Answer 26

a2

Question 27

Contract some vascular smooth muscle

Answer 27

a2

Question 28

neurotransmitters on B1 receptors

Answer 28

NE=epi

Question 29

isoproterenol has a high affinity for

Answer 29

all beta receptors

Question 30

neurotransmitters on B2 receptors

Answer 30

Epi!!!!!!!! high affinity | NE has little effect

Question 31

increase secretion of renin from the kidney

Answer 31

B1

Question 32

promote potassium uptake into skeletal muscle

Answer 32

B2

Question 33

D2 receptors

Answer 33

Inhibit adenylyl cyclase, open potassium channels, decrease Ca++ influx

Question 34

dilates renal blood vessels

Answer 34

D1

Question 35

receptor that inhibits release of transmitters from nerve terminals

Answer 35

D2

Question 36

alpha receptor effect on veins

Answer 36

contracts reservoir veins increasing filling pressure of the heart reduce venous capacity

Question 37

vessels that are more densely innervated and therefore alpha stimulation has the largest effect on them

Answer 37

small vessels

Question 38

why does alpha stimulation cause slowed heart rate

Answer 38

increases blood pressure causes baroreceptor reflex to slow heart by vagal input

Question 39

impaired baroreceptor response ---> increased sensitivity of blood pressure to alpha agonists

Answer 39

atherosclerosis

Question 40

glaucoma tx: increase removal of aqueous humor decreasing intraocular pressure

Answer 40

alpha receptor agonists

Question 41

decrease diastolic blood pressure

Answer 41

B2 (dilation of blood vessels in skeletal muscle)

Question 42

increases automaticity by increasing conduction velocity

Answer 42

beta receptor stimulation

Question 43

increases coronary blood flow

Answer 43

beta receptor stimulation

Question 44

increased rate, contractility of heart

Answer 44

beta receptor stimulation (may be countered some by reflex bradycardia)

Question 45

glaucoma tx: block increased production of aqueous humor by

Answer 45

blocking beta receptors (beta receptor antagonists)

Question 46

asthma treatment

Answer 46

B2 receptors

Question 47

treat premature contractions in pregnancy

Answer 47

relax the uterus with a B2 agonist

Question 48

your patient is hyperglycemic, what med might they be taking?

Answer 48

B2 agonist --> glycogenolysis in the liver

Question 49

your patient is hypokalemic, what medication might they be taking?

Answer 49

B2 agonist --> increased uptake of K+ into cells

Question 50

insulin secretion (a lil bit) stimulated by

Answer 50

B2 receptors