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Unit 1 Pharm II > Adrenergic stimulants general info > Flashcards

Adrenergic stimulants general info Flashcards

1
Q

tyrosine is _____ to become l dopa

A

hydroxylated

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2
Q

l dopa is ______ to dopamine

A

decarboxylated

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3
Q

DA is _______ to form NE in noradrenergic neurons synaptic vesicles

A

hydroxylated

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4
Q

rate limiting pathway of DA/NE/Epi production

A

conversion of tyrosine to l dopa (hydroxylation which occurs in cytoplasm of presynaptic knob)

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5
Q

NE is converted to epi in the

A

adrenal medulla

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6
Q

drugs that cause release of NE from the presynaptic terminal

A

tyramine
amphetamine
only have effect if the noradrenergic innervation is intact

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7
Q

a patient comes in with severe denervation and you want to provide them with sympathetic stimulation. what class of drugs aren’t going to work?

A

indirect adrenergic stimulants

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8
Q

action of NE is terminated by

A

reuptake

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9
Q

drugs which block NE reuptake

A

cocaine, antidepressants

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10
Q

MAO hangs out _________ and breaks down NE that’s _______

A

outer surface of mitochondria

released in the presynaptic terminal

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11
Q

MAO

A

monamine oxidase

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12
Q

COMT

A

catechol O methyl transferase

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13
Q

measure these in 24 hour urine to evaluate NE/Epi metabolism

A

VMA and HVA

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14
Q

VMA

A

3 methoxy 4 hydroxy mandelic aci

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15
Q

HVA

A

homovanillic acid

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16
Q

relaxation of blood vessels supplying skeletal muscle

A

B2

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17
Q

relaxation of smooth muscle in gut and bronchial tree

A

B2

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18
Q

increase rate and contractility of the heart

A

B1 B2

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19
Q

increase glycogenolysis in liver/muscle, lipolysis from adipose cells

A

B2 B3

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20
Q

3 indirect adrenergic stimulant MOAs

A
  1. increase release of NE from nerve endings
  2. inhibit reuptake of NE
  3. inhibit metabolism of NE
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21
Q

depletion of NE stores would mean that

A

indirect adrenergic stimulants can’t work

22
Q

denervation has _________ on direct acting adrenergic stimulants

A

no effect or enhances effect (receptors are up regulated, super sensitive)

23
Q

contraction of the prostate gland

24
Q

stimulate pilomotor smooth muscle causing erection of hair

25
Q

Cause aggregation of platelets

26
Q

Decrease insulin secretions

27
Q

Contract some vascular smooth muscle

28
Q

neurotransmitters on B1 receptors

29
Q

isoproterenol has a high affinity for

A

all beta receptors

30
Q

neurotransmitters on B2 receptors

A

Epi!!!!!!!! high affinity

NE has little effect

31
Q

increase secretion of renin from the kidney

32
Q

promote potassium uptake into skeletal muscle

33
Q

D2 receptors

A

Inhibit adenylyl cyclase, open potassium channels, decrease Ca++ influx

34
Q

dilates renal blood vessels

35
Q

receptor that inhibits release of transmitters from nerve terminals

36
Q

alpha receptor effect on veins

A

contracts reservoir veins increasing filling pressure of the heart
reduce venous capacity

37
Q

vessels that are more densely innervated and therefore alpha stimulation has the largest effect on them

A

small vessels

38
Q

why does alpha stimulation cause slowed heart rate

A

increases blood pressure causes baroreceptor reflex to slow heart by vagal input

39
Q

impaired baroreceptor response —> increased sensitivity of blood pressure to alpha agonists

A

atherosclerosis

40
Q

glaucoma tx: increase removal of aqueous humor decreasing intraocular pressure

A

alpha receptor agonists

41
Q

decrease diastolic blood pressure

A

B2 (dilation of blood vessels in skeletal muscle)

42
Q

increases automaticity by increasing conduction velocity

A

beta receptor stimulation

43
Q

increases coronary blood flow

A

beta receptor stimulation

44
Q

increased rate, contractility of heart

A

beta receptor stimulation (may be countered some by reflex bradycardia)

45
Q

glaucoma tx: block increased production of aqueous humor by

A

blocking beta receptors (beta receptor antagonists)

46
Q

asthma treatment

A

B2 receptors

47
Q

treat premature contractions in pregnancy

A

relax the uterus with a B2 agonist

48
Q

your patient is hyperglycemic, what med might they be taking?

A

B2 agonist –> glycogenolysis in the liver

49
Q

your patient is hypokalemic, what medication might they be taking?

A

B2 agonist –> increased uptake of K+ into cells

50
Q

insulin secretion (a lil bit) stimulated by

A

B2 receptors

Unit 1 Pharm II (18 decks)

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