Nonenzymatic Protein Function and Protein Analysis

Question 1

characteristic trihelical fiber and makes up most of the extracellular matrix of connective tissue

Answer 1

Collagen

Question 2

repetitive organization of secondary structural elements together

Answer 2

motif

Question 3

important component of ECM of connective tissue, stretch and recoil like a spring

Answer 3

elastin

Question 4

intermediate filament proteins found in epithelial cells

Answer 4

Keratins

Question 5

protein that makes up microfilaments and the thin filaments in myofibrils

Answer 5

Actin

Question 6

protein that makes up microtubules

Answer 6

Tubulin

Question 7

primary motor protein that interacts with actin, thick filament in myofibrils and involved in cellular transport

Answer 7

Myosin

Question 8

motor proteins associated with microtubules

Answer 8

Kinesin and dyneins

Question 9

proteins found on the surface of most cells and aid in the binding the cell to the ECM other cells

Answer 9

Cell Adhesion Molecules CAMs

Question 10

glycoproteins that mediate Ca-dependent cell adhesion

Answer 10

Cadherins

Question 11

proteins that have 2 membrane spanning chains alpha and beta. Important for binding and communicating with ECM. Play very important role in cell signaling

Answer 11

Integrins

Question 12

bind to carbohydrate molecules that project from other cell surfaces

Answer 12

selectins

Question 13

process in which cells receive and act on signals

Answer 13

biosignaling

Question 14

have no gates and are therefore unregulated

Answer 14

ungated channels

Question 15

gate is regulated by the membrane potential change near the channel

Answer 15

voltage-gated channels

Question 16

binding of a specific substance or ligand to the channel causes it to open or close

Answer 16

ligand-gated channels

Question 17

anchors the receptor in the cell membrane

Answer 17

membrane- spanning domain

Question 18

stimulated by the appropriate ligand and induces a conformational change

Answer 18

ligand-binding domain

Question 19

activated by the conformational change. Often results in the initiation of a second messenger cascade

Answer 19

catalytic domain

Question 20

large family of integral membrane proteins involves in signal transduction

Answer 20

G protein-coupled receptors (GPCR)

Question 21

separates proteins on the basis of mass alone

Answer 21

SDS-PAGE

Question 22

separating proteins on the basis of their isoelectric points

Answer 22

Isoelectric focusing

Question 23

uses physical and chemical properties to separate and identify compounds from a complex mixture

Answer 23

Chromatography