Carbohydrate Metabolism I Flashcards
cytoplasmic pathway that converts glucose to two pyruvate molecules, releasing a modest amt of energy captured in two-substrate level phosphorylations and one oxidation reaction
glycolysis
enzymes that control phosphorylation of glucose to glucose 6-p
Hexokinase
Glucokinase
rate limiting enzyme and main control point in glycolysis
inhibited by ATP and Citrate
activated by AMP
phosphofructokinase-1 (PFK-1)
catalyzes an oxidation and addition of inorganic phosphate to its substrate glyceraldehyde-3-phosphate
Glyceraldehyde-3-phosphate dehydrogenase
transfers high energy phosphate from 1,3-bisphosphoglycerate to ADP
3-phosphoglycerate kinase
ADP is directly phosphorylated to ATP using a high-energy intermediate
substrate-level phosphorylation
catalyzes a substrate level phosphorylation of ADP using high energy substrate Phosphoenolpyruvate PEP
Pyruvate Kinase
key fermentation enzyme which oxidizes NADH to NAD+, replenishing the oxidized coenzyme for glyceraldehyde-3-phosphate dehydrogenase
lactate dehydrogenase
conversion of pyruvate ( from glycolysis ) when enters the mitochondria to acetyl-CoA
pyruvate dehydrogenase
branched polymer of glucose, represents a storage form of glucose
Glycogen
is the synthesis of glycogen granules
glycogenesis
rate-limiting enzyme of glycogen synthesis and forms the alpha-1,4 glycosidic bond found in the linear glucose chains of the granule
Glycogen Synthase
process of breaking down glycogen
glycogenolysis
rate limiting enzyme of glycogenolysis
glycogen phosphorylase