Nonconventional Dysplasia in IBD Flashcards
Mechanism of IBD induced carcinogenesis
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Adenoma w/ high grade dysplasia
Common precursor to cancer in the general population
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Molecular mutations in IBD
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IBD, adenoma, and serrated polyp carcinoma sequences
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p53 and APC in IBD induced carcinogenesis vs typical adenoma pathway
p53 is early in IBD, but late in adenoma
Conversely, APC is late in IBD, but early in adenoma
SCENIC classification
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In IBD, nonconventional carcinogenic dysplasia may mimic. . .
. . . hyperplastic or serrated polyps in non-IBD patients
Nonconventional neoplastic lesions in IBD
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Most common types of unconventional neoplastic precurors in IBD
Hypermucinous and serrated
Unconventional dysplasia, while it itself is typically low-grade dysplastic, is often associated with. . .
. . . nearby high-grade dysplasia and high risk for carcinoma