Nonconventional Dysplasia in IBD

Question 1

Mechanism of IBD induced carcinogenesis

Answer 1

Question 1

Adenoma w/ high grade dysplasia

Answer 1

Common precursor to cancer in the general population

Question 2

Molecular mutations in IBD

Answer 2

Question 3

IBD, adenoma, and serrated polyp carcinoma sequences

Answer 3

Question 4

p53 and APC in IBD induced carcinogenesis vs typical adenoma pathway

Answer 4

p53 is early in IBD, but late in adenoma

Conversely, APC is late in IBD, but early in adenoma

Question 5

SCENIC classification

Answer 5

Question 6

In IBD, nonconventional carcinogenic dysplasia may mimic. . .

Answer 6

. . . hyperplastic or serrated polyps in non-IBD patients

Question 7

Nonconventional neoplastic lesions in IBD

Answer 7

Question 8

Most common types of unconventional neoplastic precurors in IBD

Answer 8

Hypermucinous and serrated

Question 9

Unconventional dysplasia, while it itself is typically low-grade dysplastic, is often associated with. . .

Answer 9

. . . nearby high-grade dysplasia and high risk for carcinoma