Myelodysplastic syndrome Flashcards
1
Q
MDS with del5q
A
- Only significant change is del5q (critical region is 5q3.1 to 5q3.3)
- Often assc w/ thrombocytosis
- RPS14 haploinsufficiency
1
Q
If MSD has a mutator phenotype (p53 mutation, 1/3 of cases), these may. . .
A
. . . progress to acute myeloid leukemia
1
Q
Consider CMML when you have. . .
A
. . . a myelodysplastic picture, but monocytes are persistently > 1000
2
Q
Go over signs of dysplasia in BM of various cell lines and precursors ***
A
3
Q
MDS, unclassifiable
A
- Exactly 1% dysplastic cells seen on at least 2 occasions
- Cytogenetic abnormality as evidence of MDS
- Unexplained cytopenias with insufficient features to calk MDS
