Non steroidal anti inflammatory drugs Flashcards
What are the three effects of NSAIDs?
Analgesia
Anti-inflammatory
Anti-pyretic
Describe the analgesic effect of NSAIDs
Low to moderate intensity pain
Prevent prostaglandin synthesis
How do NSAIDs prevent prostaglandin synthesis?
Phospholipids are converted to arachidonic acid by phospholipase A2
Arachidonic acid is converted to prostaglandins by cyclooxygenase which NSAIDs inhibit
How are NSAIDs antiinflammatory?
Prevent prostaglandin synthesis
How are NSAIDs anti pyretic?
Pyrogens are released by macrophages
Triggers prostaglandin release in the hypothalamus
Which drugs irreversibly inhibit cyclooxygenase?
Aspirin
Which drugs reversibly inhibit cyclooxygenase?
Ibuprofen
Which drugs non-competitively inhibit cyclooxygenase?
Paracetamol
Which drug is not anti-inflammatory?
Paracetamol
Which drug doesn’t affect the stomach?
Paracetamol
What is cyclooxygenase 1?
Constitutive enzyme
Ubiquitously expressed
Responsible for gut effects
What is cyclooxygenase 2?
Induced expression
Inflammatory cells
Mainly responsible for inflammation
What is cyclooxygenase 3?
Expressed in the brain
Target for paracetamol
Which cyclooxygenase does paracetamol inhibit?
Only 2
What makes you more susceptible to paracetamol overdose?
Smoking
Heavy drinking
Reduced liver function
