Non small cell Lung cancer

Question 1

Non small cell lung cancer treatment

Answer 1

stage 1 or 2
surgery with curative intent
adjuvent chemotherapy if high risk disease

stage 3
combined chemoradiation therapy
cisplatin based
adjuvent therapy does not improve survival

stage 4
palliative chemo and radiotherapy

bevacizumab can be used for non squamous cell cancers - monoclonal against vegf

tyrosine kinase inhibitors can be used if an activating mutation is identified

Question 2

non small cell lung cancer

Answer 2

includes several different types of cancer
squamous cell carcinoma
adenocarcinoma
large cell carcinoma

despite treatment survival at 5 years is poor. -10%
late presentation

often cause paraneoplastic syndromes

• hypercalcemia
• inflammatory arthropathies