Non-Operative Management of Lung Cancer Flashcards

1
Q

Describe the principle management of inoperable NSCLC

A
  • Surgery
  • Radiotherapy: palliative or curable?
  • Chemotherapy
  • Combination?
  • Targeted therapy
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2
Q

Describe the prognosis of non-operative management of NSCLC

A

Stage III;

  • Radical RT: 5YS = 20%
  • Chemo: 2YS = 27%

Stage IV;

  • Incurable
  • Palliation essential
  • Median survival >12 months with mono therapy

Stages III and IV chemo;

  • 3 cycles as good as 6
  • 1YS >40%
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3
Q

Describe the principle management of SCLC

A
  • Chemo of choice
  • 4 cycles of combined drugs
  • Early RT better
  • ## Prophylactic cranial radiation recommended
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4
Q

Describe other treatment strategies which are important in the palliation of lune cancer

A

a

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5
Q

Describe the ECOG performance status

A
0 = asymptomatic
1 = symptomatic, light work
2 = rest <50% of the day
3 = rest >50% of the day
4 = bedboound
5 = dead
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6
Q

Describe NSCLC adjuvant therapy

A
  • Given post-operatively
  • Chemo to increase survival
  • RT detrimental in stages I and II
  • Preoperative chemo shown to increase stage III survival
  • Use induction chemo prior to RT
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7
Q

Describe the prognosis of non-operative management of SCLC

A
  • Response rate 90%
  • Complete remission 60%
  • MS doubled with treatment: 16 months
  • 2YS = 15%
  • ED: response rate 80%
  • CR in 30%
  • MS 10x with treatment: 8 months
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