Non-Operative Management of Lung Cancer Flashcards
1
Q
Describe the principle management of inoperable NSCLC
A
- Surgery
- Radiotherapy: palliative or curable?
- Chemotherapy
- Combination?
- Targeted therapy
2
Q
Describe the prognosis of non-operative management of NSCLC
A
Stage III;
- Radical RT: 5YS = 20%
- Chemo: 2YS = 27%
Stage IV;
- Incurable
- Palliation essential
- Median survival >12 months with mono therapy
Stages III and IV chemo;
- 3 cycles as good as 6
- 1YS >40%
3
Q
Describe the principle management of SCLC
A
- Chemo of choice
- 4 cycles of combined drugs
- Early RT better
- ## Prophylactic cranial radiation recommended
4
Q
Describe other treatment strategies which are important in the palliation of lune cancer
A
a
5
Q
Describe the ECOG performance status
A
0 = asymptomatic 1 = symptomatic, light work 2 = rest <50% of the day 3 = rest >50% of the day 4 = bedboound 5 = dead
6
Q
Describe NSCLC adjuvant therapy
A
- Given post-operatively
- Chemo to increase survival
- RT detrimental in stages I and II
- Preoperative chemo shown to increase stage III survival
- Use induction chemo prior to RT
7
Q
Describe the prognosis of non-operative management of SCLC
A
- Response rate 90%
- Complete remission 60%
- MS doubled with treatment: 16 months
- 2YS = 15%
- ED: response rate 80%
- CR in 30%
- MS 10x with treatment: 8 months