Non-Neoplastic Skin Diseases

Question 1

What does epidermal hyperplasia reflect?

Answer 1

Reflects chronic irritation or altered turnover or keratinocytes

Question 2

List 6 histopathological features of type 1 hypersensitivity.

Answer 2

Epidermal hyperplasia
Spongiosis
Hyperkeratosis and follicular keratosis
Dermal oedema
Superficial perivascular dermatitis involving mast cells and eosinophils
Late stage mononuclear cell infiltrate

Question 3

List three characteristics of perivascular dermatitis with epidermal spongiosis

Answer 3

Intercellular oedema due to vascular exudate
Acute
If progresses may rupture intercellular bridges and form a spongiotic vesicle

Question 4

List three characteristics of interface dermatitis

Answer 4

Thick BMZ or clefting
Apoptotic keratinocytes
Hydropic degeneration basal keratinocytes

Question 5

List two causes of bacterial granulomatous dermatitis

Answer 5

Staphylococcus
Actinomyces/Nocardia

Question 6

How does a pustule form?

Answer 6

Breakdown intercellular bridges (acantholysis)
Vesicle (bulla) formation
Fluid and acantholytic keratinocytes gather and neutrophils/eosinophils gather.
Pustule is formed

Question 7

How do hair follicles develop into furunculosis?

Answer 7

Perifolliculitis, folliculitis and furunculosis

Question 8

What is panniculitis?

Answer 8

Inflammation of fat

Question 9

What may telogen follicles be caused by?

Answer 9

Hyperadrenocorticism
Hypothyroidism
Oestrogen-related