Crusting, Ulceration and Erosions Flashcards
What is the average age of onset of canine pemphigus foliceus?
Approximately two to seven years
Where are canine pemphigus foliaceus skin lesions usually found?
Face (periocular, nasal planum, muzzle) and pinnae
Footpads often involved (can be the only area affected)
Trunk
What do the primary and secondary lesions of canine pemphigus foliaceus?
Primary - vesicles and pustules
Secondary - crusting and erosions
What is seen on the histopathology of pemphigus foliaceus?
Intraepidermal and/or intrafollicular pustules with abdunant acantholytic keratinocytes in the granular or upper spinous cell layers
What is the immunopathology of pemphigus foliaceus?
Anti-keratinocyte membrane auto-antibodies demonstrated by direct immunofluorescence in up to 80% of cases. Usually IgG
What has been recorded as an underlying cause for feline pemphigus foliaceus?
Drug eruption
Where are feline pemphigus foliaceus lesions usually seen?
Usually seen on the head - especially pinnae, nasal planum
What will cytology of feline pemphigus foliaceus reveal?
Numerous neutrophils (eosinophils) with acantholytic keratinocytes
What are the three drugs used in the treatment of pemphigus?
Glucocorticoids
Azathioprine
Chlorambucil
What is the name of the condition where there is photosensitive dermatosis that involves the nasal planum?
Canine discoid lupus erythematosus (facial DLE)
List five clinical features of ulcerative pastern dermatitis
More common on hind pasterns
Cellulitis, ulceration and crusting, oedema
Fissuring occur because of the mobility of the skin
Granulation tissue may be excessive if healing is delayed
Lameness
