Non-insulins

Question 1

Metformin (brands)

Answer 1

Glucophage, Fortamet, Glumetza

Question 2

Metformin efficacy

Answer 2

A1C ↓ 1.5-2.5%
FBG ↓ 60-80 mg/dL
Not major change in weight

Question 3

SGLT2 Inhibitors (brands)

Answer 3

Canagliflozin (Invokana)
Dapagliflozin (Farxiga)
Empagliflozin (Jardiance)
Ertugliflozin (Steglatro)

Question 4

SGLT2 Inhibitors efficacy

Answer 4

A1C ↓ 0.5-1%
FBG ↓ 25-35 mg/dL
Weight ↓ 1-5kg
↓ BP

Question 5

GLP1 Agonists (brands)

Answer 5

Liraglutide (Victoza)
Dulaglutide (Trulicity)
Semaglutide (Ozempic)
Exenatide (Byetta)
Lixisenatide (Adylyxin)

Question 6

GLP1 Agonists efficacy

Answer 6

A1C ↓ 0.7-1.6%
Weight ↓ 1.5-3kg

Question 7

Metformin dosing

Answer 7

Initial 500mg po bid or 850mg po qd
Titrate 250-500mg/day every 3-7 days
Max 2g/day

Question 8

Canagliflozin / Invokana dosing

Answer 8

Initial 100mg po qd
Max 300mg po qd

Question 9

Dapagliflozin / Farxiga dosing

Answer 9

Initial 5mg po qd
Max 10mg po qd

Question 10

Empagliflozin / Jardiance dosing

Answer 10

Initial 10mg po qd
Max 25mg po qd

Question 11

Ertugliflozin / Steglatro dosing

Answer 11

Initial 5mg po qd
Max 15mg po qd

Question 12

Dulaglutide / Trulicity dosing

Answer 12

0.75mg - 4.5mg subq once weekly

Question 13

Semaglutide / Ozempic dosing

Answer 13

Initial 0.25mg x 4 weeks
0.5mg - 2mg subq once weekly

Question 14

Liraglutide / Victoza dosing

Answer 14

Initial 0.6mg x 1 week
1.2mg - 1.8mg subq qd

Question 15

Dual GLP1 + GIP (brand)

Answer 15

Tirzepatide (Mounjaro)

Question 16

Dual GLP1 + GIP efficacy

Answer 16

A1C ↓ 1.5-2.3%
FBS ↓ 40-60%
Weight ↓ 6-11kg

Question 17

Tirzepatide / Mounjaro dosing

Answer 17

Initial 2.5mg subq once weekly
Titrate 2.5mg changes once monthly
Max 15mg subq once weekly

Question 18

DPP4 Inhibitors (brands)

Answer 18

Sitagliptin (Januvia)
Saxagliptin (Onglyza)
Linagliptin (Tradjenta)
Alogliptin (Nesina)

Question 19

DPP4 Inhibitors efficacy

Answer 19

A1C ↓ 0.5-1%
FBS ↓ 20 mg/dL
Weight ↓ 0-0.5kg (weight neutral)

Question 20

Sitagliptin / Januvia dosing

Answer 20

CrCl > 50 – 100mg po qd
CrCl 30-50 – 50mg po qd
CrCl < 30 – 25mg po qd

Question 21

Saxagliptin / Onglyza dosing

Answer 21

CrCl > 50 – 2.5-5mg po qd
CrCl < 50 – 2.5mg po qd

Question 22

Linagliptin / Tradjenta dosing

Answer 22

5mg po qd

Question 23

Alogliptin / Nesina dosing

Answer 23

CrCl > 60 – 25mg po qd
CrCl 30-60 – 12mg po qd
CrCl < 30 – 6.25mg po qd

Question 24

Sulfonylureas (brands)

Answer 24

Glyburide (Micronase, Diabeta)
Micronized Glyburide (Glynase)
Glipizide (Glucotrol, Glucotrol XL)

Question 25

Sulfonylureas efficacy

Answer 25

A1C ↓ 1-2% FBG ↓ 60-70 mg/dL

Question 26

Glipizide / Glucotrol dosing

Answer 26

Start 2.5-5mg po qd Increase q1-2 weeks Max 40mg po qd

Question 27

Glipizide / Glucotrol XL dosing

Answer 27

Start 2.5-5mg po qd Increase q1-2 weeks Max 20mg po qd

Question 28

Gliburide / Micronase, Diabeta dosing

Answer 28

Start 1.25-5mg po qd Increase q1-2 weeks Max 20mg po qd

Question 29

Micronized Gliburide / Glynase dosing

Answer 29

Start 1.5-3mg po qd Increase q1-2 weeks Max 12mg po qd

Question 30

Thiazolidinediones (brands)

Answer 30

Pioglitazone (Actos) Rosiglitazone (Avandia)

Question 31

Thiazolidinediones efficacy

Answer 31

A1C ↓ 0.5-1.5% FBG ↓ 60-70mg/dL

Question 32

Pioglitazone / Actos dosing

Answer 32

Start 15-30mg po qd Increase q12 weeks Max 30-45mg po qd