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PHRM844 > Antihyperlipidemics > Flashcards

Antihyperlipidemics Flashcards

1
Q

First statin approved

A

1987

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2
Q

Cholesterol function

A

Component of cell membranes
Precursor to sterols and steroids

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3
Q

Triglyceride function

A

Storage form of fuel
Component of structural lipids

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4
Q

Lipoprotein classed by

A

Density
Composition
Electrophoretic mobility

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5
Q

Major classes of lipoproteins

A

Chylomicrons
VLDL
IDL
LDL
HDL

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6
Q

Chylomicron function

A

Transport dietary lipids from gut to liver and tissue

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7
Q

VLDL

A

Secreted by liver into blood
Source of TGs

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8
Q

IDL

A

VLDLs without TGs

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9
Q

LDL

A

Main cholesterol form in blood

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10
Q

HDL

A

Secreted by liver
Acquire cholesterol from peripheral tissue

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11
Q

ApoA-I

A

Prod in liver and intestine
Structural in HDL
Mediates reverse cholesterol transport

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12
Q

ApoB-100

A

Produced in liver
Structural in VLDL, IDL, LDL

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13
Q

ApoB-48

A

Produced in intestine
Structural in chylomicrons

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14
Q

ApoE

A

Produced in liver and other tissues
Reverse cholesterol transport with HDL

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15
Q

ApoCII

A

Found in chylomicrons
Binds lipoprotein lipase to enhane TG hydrolysis

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16
Q

LPL (lipoprotein lipase)

A

In capillaries of fat, cardiac and skeletal muscle

17
Q

HL (hepatic lipase)

A

Produced in liver
Key in converting IDL to LDL

18
Q

LCAT (lethicin-cholesterol acyltransferase)

A

On LDL and HDL

19
Q

CETP (cholesterol ester transfer protein)

A

In blood

20
Q

Cholesterol formation

A

Takes place in liver
De novo from acetyl-CoA

21
Q

Hyperlipoproteinemia

A

Atherosclerosis (accumulation of cholesterol in vasc smooth musc)
Premature CAD
Neurologic disease - stroke

22
Q

Hypertriglyceridemia

A

Pancreatitis
Xanthomas
Incr ridk of CHD

23
Q

Cholesterol levels and CHD

A

10% decr in cholesterol levels -> ~10-30% decr incidence of CHD

24
Q

Drugs mainly for high cholesterol

A

Bile acid binding resins
Cholesterol abs inhibitors
Cholesterol synth inhibitors
PCSK9 inhibitors
MTTP inhibitors

25
Q

Drugs mainly for high TGs

A

Fibrates
Niacin
Omega 3 fatty acids

PHRM844 (16 decks)

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