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IHO Week 4 (MJ) > Non Hodgkin Lymphoma > Flashcards

Non Hodgkin Lymphoma Flashcards

1
Q

Basics of Leukemia

A

Malignancy of hematopoietic cells
Starts in bone marrow (can spread to blood, nodes)
Myeloid or Lymphoid
Acte or Chronic

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2
Q

Basics of Lymphoma

A

Malignancy of hematopoietic cells
Starts in lymph nodes (can spread to marrow, blood)
Lymphoid only
Hodgkin or Non Hodgkin

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3
Q

What is the most common cause of lymphadenopathy?

A

benign reaction to infection

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4
Q

Most common cause of malignant lymphadenopathy?

A

Metastatic carcinoma

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5
Q

Where are most follicles located?

A

In cortex, under the capsule (lymphocytes with germinal centers)

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6
Q

Where does cell differentiation and maturation occur

A

Germinal center and mantle zone

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7
Q

Follicular hyperplasia

A

B cell response to immune stimulus
Tingible macrophages
Large irregular follicles

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8
Q

Tingible macrophages in Lymphoma…

A

NONE

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9
Q

Interfollicular hyperplasia

A

Expanded area between follicles
Mixture of cells
Partial effacement (normal architecture obliterated)
T cell response to some type of stimuli.

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10
Q

Non Hodgkin Lymphoma

A

Malignant proliferation of lymphoid cells (blast or mature cells) in lymph nodes
Skips around
Mostly B cells

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11
Q

Non Hodgkin vs Hodgkin

A

Non Hodgkin tends to skip around more, has a worse prognosis because it is unpredicable

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12
Q

Symptoms of NHL

A

painless, firm lymphadenopathy
extranodal manifestations
B symptoms

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13
Q

What are B symptoms

A

Weight loss
Night Sweats
Fever

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14
Q

A

A

no B symptoms

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15
Q

Low Grade NHL

A

Older patients
Indolent (not a lot of mitosis)
Small, mature cells
Non destructive

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16
Q

High Grade NHL

A

Children
Aggressive
Big ugly cells
Destructive

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17
Q

Types of Low Grade (4)

A
  1. Small lymphocytic lymphoma
  2. Malt lymphoma
  3. Follicular lymphoma
  4. mycosis fungoides
18
Q

Types of High Grade (3)

A
  1. Large Cell lymphoma
  2. Lymphoblastic lymphoma
  3. Burkitt Lymphoma
19
Q

Small Lymphocytic Lymphoma

A

CLL
small mature lymphocytes
B cell, CD5+

20
Q

What is Richter’s Transformation?

A

Change from low grade lymphoma/leukemia to a high grade process - cells get bigger and become more aggressive

21
Q

Marginal Zone Lymphoma

A

Actually a bunch of lymphomas
Marginal zone pattern
MALT lymphoma

22
Q

What is MALT Lymphoma associated with?

A

H. Pylori

If catch early, antibiotic and goes away

23
Q

Mantle Cell Lymphoma

A

Mantle zone pattern
Small angulated lymphocytes
T (11;14) cyclin D and IgH
Aggressive

24
Q

Mantle Cell translocation?

A

T(11;14)

25
Q

Follicular Lymphoma

A

Follicular pattern (later diffuse)
Small cleaved cell (1), mixed (2) or large cell (3)
T (14;18) IgH and Bcl-2
Butt cells

26
Q

Butt cells

A

Follicular lymphoma

27
Q

Follicular lymphoma translocation?

A

T (14;18)

28
Q

Stage I

A

Single Node

29
Q

Stage II

A

Two or more nodes on the same side of the diaphragm

30
Q

Stage III

A

Lymph nodes on both sides of the diaphragm

31
Q

Stage IV

A

Diffuse extranodal involvement

32
Q

A

A

No additional symptoms

33
Q

B

A

weight loss, night sweats, fever

34
Q

Mycosis Fungoides/Sezary Syndrome

A 
Skins lesions (MF), present as flat lesions like eczema
Starts as patch - then plaque - nodule
Blood involvement (SS)
Cerebriform lymphocytes
T cell immunophenotype
35
Q

Cerebriform lymphocytes

A

Mycosis Fungoides / Sezary Syndrome

36
Q

Diffuse Large Cell Lymphoma

A

Large B cells
Extranodal involvement
Grows rapidly
Bad prognosis

37
Q

Lymphoblastic Lymphoma

A

Two types: B and T
Lymphoblasts in diffuse pattern
same thing as ALL

38
Q

How does lymphoblastic lymphoma present?

A

Teenage Male
Mediastinal Mass (Thymus)
T-lymphoblastic

39
Q

Burkitt Lymphoma presentation

A

Child with fast growing extranodal mass

40
Q

Burkitt Lymphoma pattern?

A

Starry sky

FAST GROWING

41
Q

Burkitt Lymphoma translocation

A

T (8;14) cmyc and IgH

42
Q

Adult T cell Leukemia/Lymphoma

A

Japan/Caribbean basin
HTLV-1
Skin lesions, hypercalcemia
Aggressive

IHO Week 4 (MJ) (10 decks)

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