Hodgkin Lymphoma Flashcards
Who gets Hodgkin Lymphoma
Younger patients (means good prognosis)
Pattern of Hodgkin?
Contiguous (predicable manner, doesn’t go sporadically)
What is critical in Hodgkin prognosis?
Stage
Hallmark cell of Hodgkin?
Reed-Sternberg cell
What does a Reed-Sternberg cell look like?
Big nuclei (2), big nucleolus, Owl eye appearance
Tumors in Hodgkins…
Background cells make bulk and are not malignant.
Reed-Sternberg are what are the bad ones
Subtypes of Hodgkin
Nodular lymphocyte-predominance Hodgkin Lymphoma Nodular Sclerosis Lymphocyte Rich Mixed Cellularity Lymphocyte Depletion
Nodular L-P Hodgkin
Asymptomatic young males cervical lymphadenopathy Good prognosis B cell origin popcorn cell
Nodular Sclerosis
Most common
Good prognosis
Lacunar cells
Mixed Ceullarity
Classic Reed-Sternberg
Disseminated at presentation
Background cells
worse prognsis
Lymphocyte Rich
Uncommon
Localized
Popcorn cells
Lymphocyte Depletion
Rare
Disseminated at presentation
Reed-Sternberg
Collagen or Reticulin background
Treatment of Hodgkin
Chemo, Surgery, Radiation
What is the main danger of Hodgkin?
Second malignancy (due to chemo/radiation)
