Immunotherapy

Question 1

4 parts of the holy grail

Answer 1

cytokines
vaccines
tumor infiltrating lymphocytes (tils)
Antibodies to tumor specific antigens

Question 2

Problems with TILs and Gene (IL-2) Transfer

Answer 2

expensive and complex, anergy

Question 3

Rituximab

Answer 3

Chimeric antibody against CD20, membrane protein of B lymphocytes

Question 4

Rituximab induces….

Answer 4

antibody dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC)

Question 5

What is Rituximab useful for?

Answer 5

B cell malignancy and auto immune disease

Question 6

RCHOP

Answer 6

Hodgkin’s Lymphoma ( I think…)

Question 7

Anti-CD20

Answer 7

Ofatumumab
Obinutuzumab
Outperform rituximab - low grade lymphomas

Question 8

blockade of the inhibitory effects of CTLA-4 can allow for and potentiate…

Answer 8

immune response against tumor cells

Question 9

B7 to CTLA-4

Answer 9

Off switch, blocks B7 and CD28

Question 10

Ipilimumab

Answer 10

blocks B7 and CTLA-4. Turns off the off switch. Dendritic cells and T cells interact. Activation

Question 11

Side effects of CTLA-4 blockade?

Answer 11

colitis
rash
endocrinopathies
pulmonary toxicity

Question 12

PD1 and PD1 ligand

Answer 12

another off switch, surpresses T cell activation

Question 13

Advantage to PD1

Answer 13

kinder, less side effects

Question 14

What if you block PD-1 and PD1 ligand?

Answer 14

T cell can be activated and attack tumor cell

Question 15

What types of cancer is PD1 and PD1 ligand blockade effective in?

Answer 15

mismatch repair and mutations of high genetic variation

Question 16

Side effects of PD1 blockade?

Answer 16

Skin (rash), colitis and thyroid problems