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Hematology > Non Hodgkin Lymphoma > Flashcards

Non Hodgkin Lymphoma Flashcards

1
Q

Compare age distribution of Hodgkin lymphoma to non Hodgkin lymphoma

A

Hodgkin lymphoma => bimodal 15-35 and above 50

Non Hodgkin lymphoma => more than 50 yo

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2
Q

Compare male to female ratio in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => 5:1 for male

Non Hodgkin lymphoma => 1.7:1 for male

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3
Q

Compare stage of presentation in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => I and II

Non Hodgkin lymphoma => III and IV

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4
Q

Compare percentage of B symptoms in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => 25-40%

Non Hodgkin lymphoma => 15%

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5
Q

Compare spread of disease in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => predictable centripetal or axial spread to contiguous lymph nodes

Non Hodgkin lymphoma => random spread

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6
Q

Compare leukemia phase presence in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => rare

Non Hodgkin lymphoma => common

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7
Q

Compare percentage of nodal and extranodal origin tumor in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => more than 95% nodal in origin

Non Hodgkin lymphoma => 80% nodal , 20% extranodal

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8
Q

Compare involvement or not of Trochlear , mesenteric or pharyngeal nodes in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => rare

Non Hodgkin lymphoma => common

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9
Q

Compare mediastinal involvement percentage in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => 50%

Non Hodgkin lymphoma => 20%

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10
Q

Compare bone marrow involvement percentage in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => less than 10%

Non Hodgkin lymphoma => 70%

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11
Q

Compared GIT and liver involvement in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => rare

Non Hodgkin lymphoma => commoner

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12
Q

Compre contiguous spread or not from lymph nodes in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => yes

Non Hodgkin lymphoma => no

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13
Q

Compare superior vena cava oncstruction in Hodgkin lymphoma and non Hodgkin lymphoma

A

Hodgkin lymphoma => rare

Non Hodgkin lymphoma => common

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14
Q

Do we know etiology of non Hodgkin lymphoma

A

No

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15
Q

Factors that play role in non Hodgkin lymphoma

A

EBV
HTLV1
Immunosupression

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16
Q

2 types of cellular infection by EBV

A

Latent

Cellular

17
Q

Which type of EBV infection linked with non Hodgkin lymphoma

A

Latent

18
Q

Three types of EBV latency with genes and disease entity caused

A
19
Q

Types of non Hodgkin lymphoma

A

Aggressive
Indolent
B cells lymphomas
T cell lymphomas

20
Q

Aggressive non Hodgkin lymphoma types

A 
Diffuse large B cell lymphoma 
Anaplastic large cell lymphoma 
Burkitt lymphoma 
Lymphoblastic lymphoma 
Mantle cell lymphoma 
Peripheral T cell lymphoma
21
Q

Indolent non Hodgkin lymphoma types

A 
Follicular lymphoma 
Cutaneous T cell lymphoma 
Lymphoplasmacytic lymphoma 
Marginal zone B cell lymphoma 
MALT lymphoma 
Small cell lymphocytic lymphoma
22
Q

B cell lymphoma types

A 
Diffuse large B cell lymphoma 
Follicular lymphoma 
Mantle cell lymphoma 
Marginal zone lymphoma 
Burkitt lymphoma 
Lymphoplasmcytic lymphoma
23
Q

T cell lymphomas

A

Cutaneous T cell lymphomas
Angioimmunoblastic T cell lymphoma
Anaplastic large cell lymphoma
Enteropathy type T cell lymphoma

24
Q

Can we use same staging of Hodgkin lymphoma in non Hodgkin lymphoma

A

Yes

25
Q

Investigations in non Hodgkin lymphoma

A

Waldeyer group of LNs inspection
Bone biopsy
Laparotomy sometimes

26
Q

To say that there’s positive LN involvement , what size shou you measure

A

More than 1.5 cm

27
Q

How do you attest spleen involvement

A

Imaging

28
Q

How do you determine intrathoracic involvement

A

CX ray

29
Q

How do you determine chest, abdomen, pelvis involvement

A

CT

30
Q

How do you identify abnormal LN

A

Lymphangiography

31
Q

How do you identify bone disease and card compression

A

MRI

32
Q

Clinical features

A

Widespread painless LN
Hepatosplenomegaly
20-30% with B presentation

33
Q

Main extranodal disease in Burkitt lymphoma

A

Jaw in Africa

GIT and other abdominal sites in West

34
Q

Symptoms of lymphoblastic lymphoma

A

Thymic mass
Systemic symptoms
Bone marrow failure

35
Q

Management of non Hodgkin lymphoma based on type ?

A

Yes

36
Q

Do half of patient that experienced complete remission from non Hodgkin lymphoma relapse in 5 years

A

Yes

37
Q

Treatment in advanced disease

A

Anthracycline containing regimen

Fludarabine based regiment

38
Q

Can you repeat combination therapy if failure

A

Yes after Long period of remission

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