Introduction Flashcards
Composition of blood
Plasma - 55%
Red blood cells - 45%
Buffy coat - <1%
Buffy coat composition
WBC
Platelets
Composition of plasma
Proteins (albumin, fibrinogen, globulin) Electrolytes Gases Metabolic products and wastes Hormones
Cellular components of blood
Red cells
White cells (neutrophils, monocytes, eosinophils, lymphocytes, basophils )
Platelets
What is haemopoeisis
Formation of blood cells (red cells, white cells, platelets)
When does hemopoeisis starts
In utero
Site of hematopoeisis from 0-2months
Yolk sac
Site of hemopoeisis from 2-7 months
Liver and spleen
Site of hemopoeisis 5-9 months
Bone marrow
Main organs involved in hematopoeitic cell maturation
Bone marrow
Thymus
Spleen
Lymph nodes
How can you observe development of indivuald blood cells
Bone marrow sampling
What are the two ways to do bone marrow sampling
Aspiration
Trephine biopsy
Where on body do you do bone marrow aspiration
Back , iliac crest
What are the requirements for cells growth in bone marrow
Building blocks
Growth factors
Cell signaling
Metabolic processes
Main growth factor for erythropoeisis
Erythropoietin