Non-DHP Calcium Channel Blockers (week 4)

Question 1

What are the two non-DHP CCBs?

Answer 1

diltiazem and verapamil

Question 2

What are the brand names for diltiazem?

Answer 2

Cardizem, Cardizem CD, Cardizem LA, Cardia XT, Tiazac

Question 3

What are the brand names for verapamil?

Answer 3

Calan, Calan SR, Verelan

Question 4

How do non-DHP CCBs lower blood pressure?

Answer 4

block calcium from entering cell membranes and block conduction in the heart

Question 5

What are the FDA approved indications for non-DHP CCBs?

Answer 5

abnormal heart rate (atrial fibrillation, arrhythmia), hypertension and angina

Question 6

What are the adverse effects of non-DHP CCBs?

Answer 6

low heart rate and blood pressure, constipation and overgrowth of gums (gingival hyperplasia)

Question 7

What are the drug interactions for non-DHP CCBs?

Answer 7

1. beta blockers, digoxin, amiodarone (dual heart rate slowing)
2. Carbamazepine (decreases blood pressure effects of verapamil/diltiazem)

Question 8

What is the box warning for non-DHP CCBs?

Answer 8

no box warning, only precautions

Question 9

What are the precautions for non-DHP CCBs?

Answer 9

caution in liver/renal dysfunction, heart failure and abnormal heart conduction conditions

Question 10

What are the patient counseling points for non-DHP CCBs?

Answer 10

counsel on adverse effects and that contents for sustained release can be sprinkled on food and should be taken with food or milk