DHP CCBs (week 5)

Question 1

DHP CCBs include which two drugs?

Answer 1

amlodipine and amlodipine/benazepril

Question 2

What is the brand name of amlodipine?

Answer 2

Norvasc

Question 3

What is the brand name of amlodipine/benazepril?

Answer 3

Lotrel

Question 4

How do DHP CCBs lower blood pressure?

Answer 4

they block calcium from entering cell membranes, resulting in greater dilation of blood vessels throughout the body

Question 5

What are the FDA approved indications for DHP CCBs?

Answer 5

chest pain (angina), high blood pressure

Question 6

What are the adverse effects associated with DHP CCBs?

Answer 6

peripheral edema (swelling of the legs), flushing, dizzinness/lightheadedness - serious: orthostasis

Question 7

What are the drug interactions for DHP CCBs?

Answer 7

taking with a diuretic creates additive risk for low blood pressure, taking with simvastatin increases statin levels

Question 8

What is the box warning for DHP CCBs?

Answer 8

no box warning

Question 9

What are the precautions for DHP CCBs?

Answer 9

starting at a lower dose in elderly, caution in liver impairment

Question 10

What are the patient counseling points for DHP CCBs?

Answer 10

do not stop abruptly, counsel on signs and symptoms of swelling and low blood pressure (specifically orthostasis)