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Top 200 Drugs > Cholesterol medications part 1 - statins (week 6) > Flashcards

Cholesterol medications part 1 - statins (week 6) Flashcards

1
Q

What is the brand name of atorvastatin?

A

Lipitor

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2
Q

What is the brand name of atorvastatin/amiodipine?

A

Caduet

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3
Q

What is the brand name of ezetimibe/simvastatin?

A

Vytorin

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4
Q

What is the brand name of lovastatin?

A

Mevacor, Altoprev

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5
Q

What is the brand name of pravastatin?

A

Pravachol

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6
Q

What is the brand name of rosuvastatin?

A

Crestor

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7
Q

What is the brand name of simvastatin?

A

Zocor

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8
Q

Statins are also known as

A

HMG-CoA reductase inhibitors

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9
Q

What is cholesterol?

A

waxy substance ingested from dietary sources and synthesized by the liver

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10
Q

What are triglycerides associated with?

A

eating

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11
Q

What are lipoproteins?

A

complexes of lipids and proteins that transport lipids throughout the body

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12
Q

Which cholesterol is “bad”?

A

LDLs - lead to fatty plaque build up -restricted blood flow and cardiovascular disease risk

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13
Q

Which cholesterol is “good”?

A

HDLs - remove cholesterol from arteries and prevent deposits

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14
Q

What is dyslipidemia?

A

a risk factor for cardiovascular disease characterized by low levels of HDL and high levels of LDL

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15
Q

What do drugs for dyslipidemia usually target?

A

target cholesterol synthesis in the form of elevated LDLs - enhance clearance of buildup

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16
Q

What are the FDA-approved indications for statins?

A

hyperlipidemia (high LDL), primary and secondary prevention of cardiovascular disease, familial hypercholesterolemia

17
Q

What are the adverse effects associated with statins?

A

muscle aches/pains (myalgias and rhabdomyolysis), elevated liver enzymes and elevated blood glucose

18
Q

What are myalgias?

A

pain in muscle or group of muscles

19
Q

What is rhabdomyolysis?

A

destruction of striated muscle cells

20
Q

What drugs affect statins?

A

Gemfibrozil, warfarin, CCBs, macrolide antibiotics

21
Q

What is the boxed warning for statins?

A

no boxed warning

22
Q

What are the contraindications for statins?

A

pregnancy and lactation

23
Q

What are some cautions for statin use?

A

hepatic impairment/heavy alcohol consumption, diabetes (due to elevated glucose levels)

24
Q

What are the clinical pearls for statins?

A

drug interactions are least likely with hydrophilic statins and patients can try different statins if they experience muscle pain

Top 200 Drugs (24 decks)

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