NMBD PharmK/D

Question 1

Succinylcholine
Dose, onset

Answer 1

Induction: 0.5 to 1 mg/kg Infusion: 2 to 5 mg
Onset: 30 to 60s

Question 2

Rocuronium
Dose, onset

Answer 2

Induction: 0.6 to 1 mg/kg Infusion: 5 to 10 mcg/kg/min Onset: 1 to 2 min

Question 3

Pancuronium
Induction Dose,
onset

Answer 3

Induction: 0.1 mg/kg ;
Onset: 3 to 4 min

Question 4

Atricuronium
Dose, onset

Answer 4

Induction: 0.5 mg/kg ;
Infusion: 4 to 12 mcg/kg/min Onset: 3 to 4 min

Question 5

Cisatricuronium
Dose, onset

Answer 5

Induction: 1 to 5 mcg/kg/min Infusion: 1 to 5 mcg/kg/min Onset: 2 to 3 min

Question 6

Vecuronium
Dose

Answer 6

Induction: 0.1 ,
infusion: 0.8-2 mcg/kg/min;
Onset: 3-4 min

Question 7

Succinylcholine
Duration, Elimination

Answer 7

Duration to 25% twitch height: 6 to 8min;
Duration to TOF 0.9+: RSI 10 to 12 min ;
Elimination Plasma cholinesterase (hydrolysis) duration depends on diffusing to vs from junction

Question 8

Rocuronium
Duration, Elimination

Answer 8

Duration to 25% twitch height 30 to 40 min;
Duration to TOF 0.9+: 55 to 80 ;
Elimination Renal 30% and Hepatic 70%

Question 9

Pancuronium
Duration, Elimination

Answer 9

Duration to 25% twitch height; 80 to 120
Duration to TOF 0.9+ 130 to 220:
Elimination Hepatic 70 Renal 10 to 20

Question 10

Atricuronium
Duration, Elimination

Answer 10

Duration to 25% twitch height: 30-45;
Duration to TOF 0.9+: 55-80
Elimination Hoffmann and Nonsp-ecific esterases

Question 11

Cisatricuronium
Duration, Elimination

Answer 11

Duration to 25% twitch height: 45-60 ;
Duration to TOF 0.9+: 60-90 ;
Elimination Hoffman

Question 12

Vecuronium
Duration, Elimination

Answer 12

Duration to 25% twitch height: 35 to 40 ;
Duration to TOF 0.9+: 50 to 80 ;
Elimination Hepatic, Renal 50,50

Question 13

Edrophonium:
Dose, Peak, Duration,

Answer 13

Dose: 0.5 to 1 mg/kg
Peak: 1-3 min
Duration: 45-60 min

Question 14

Neostigmine:
Dose, Peak, Duration,

Answer 14

Dose: 0.03-0.07 mg/kg (up to 5mg)
Peak: 7-10 min
Duration : 55-75 min

Question 15

Pyridostigmine:
Dose, Peak, Duration,

Answer 15

Dose: 0.1-0.4 mg/kg
Peak:15-20 min
Duration: 80-130 min

Question 16

Edrophonium:
Elimination: Atropine vs Glyco:

Answer 16

Atropine: 7-10 mcg/kg

Glyco: 10-15 mcg/kg

Elimination: 30% hep

Question 17

Neostigmine:
Elimination, Atropine, Glyco:

Answer 17

Atropine: 15-30 mcg/kg
Glyco: 10-15 mcg/kg
Elimination: 50% hep

Question 18

Pyridostigmine:
Elimination, Atropine, Glyco:

Answer 18

Atropine: 15-20 mcg/kg
Glyco: 10 mcg/kg duration inc with CKD

Elimination: 75% hep

Question 19

Sugammadex: Dosing

Answer 19

depends on NMBD;

Routine Reversal 4mg/kg after recovery to 1-2 posttetanic twitches,

2 mg/kg after recovery to 2 TOF twitches.

Reversal of Induction bolus of rocuronium: 16 mg/kg