Hypnotic Pharmcokinetics/math

Question 1

Propofol

Dose/Onset/ Distribution Duration/0.5

Answer 1

Induction: 1-2.5 mg/kg ~100
Infusion: 100 to 200 mcg/kg/min
Sedation:25-75 mcg/kg/min
On: 15 to 45 sec
Dur: 5 to 10 min

0.5 Life: 2 to 24 min

Question 2

Thiopental

Dose/Onset/Duration; Distribution/ 0.5 Life

Answer 2

Induction: 3-5 mg/kg ~280
GA: 30-70 mcg/kg/min
On: 15 to 45 sec
Dur: 5 to 10 min
0.5 Life:12 hr

Question 3

Methohexital

Dose/Onset/Duration 0.5 Life

Answer 3

Induction: 1-2mg/kg ~100
GA: 50 to 150 mcg/kg/hr
On: 15 to 30 sec
Dur: 5 to 10 min

0.5 Life: 4 hr

Question 4

Etomidate

Dose/Onset/Duration; Distribution/ 0.5 Life

Answer 4

Induction: 0-2 to 0.3 mg/kg
GA: 10 mcg/kg/min
On: 15 to 45 secs
Dur: 3-10 min

0.5 Life: 3 to 5

Question 5

Ketamine

Dose/Onset/Duration; Distribution/ 0.5 Life

Answer 5

Induction: 1-2 mg/kg (70-140 mg) (IM x3) (PO x 5)
Infusion: 30 to 90 mcg/kg/min
Adjunct 0.1 mg/kg/h

On:IV 30 to 60s, IM 3 to 4 min, po 20 to 40 min
Dur: 5-10 min IV, 10 to 25 IM

0.5 Life: 2-4 min

Question 6

Precedex

Dose/Onset/Duration; Distribution/ 0.5 Life

Answer 6

LOading 10 mcg/kg
Infusion: 1 mcg/kg/min
Sedatin: 0.2 to 1.4 mcg/kg/min

0.5 Life: 2 to 3 min

Question 7

Midazolam

Dose/Onset/Duration; Distribution/ 0.5 Life

Answer 7

Adult premed 1to2mg
Induction .2-0.4mcg/kg/min
On: 1 to 3 min iV premed,
0.5 to 1.5min iv induction
15 to 30 min PO induction 

Peak 3 to 5 min for IV, 20 to 50 min PO

0.5 Life: 1.8 to 6.4, active metabolites

Question 8

Propofol

Protein Binding/Elimination

Answer 8

Protein Binding: 98%
Elimination: 2 to 24 min via Hepatic and Extra Hepatic Clearance to inactive metabolite, minimal effect from Renal and Liver dz

Question 9

Thiopental

Protein Binding/Elimination/acid base interaction

Answer 9

Protein Binding: 83%
Elimination: From US market
Precipitates with acids e.g. nmbd or in tissue injury with extravasation.

Question 10

Methohexital

Protein Binding/Elimination/Clearance

Answer 10

Protein Binding: 73%
Elimination: clearance via hepatic clearance very quickly
Clearance: 4 ml/kg/min

Question 11

Etomidate

Protein Binding/Elimination/Clearance

Answer 11

Protein Binding: 77%
Elimination:
Clearance: 18-25 ml/kg/min

Question 12

Ketamine

Protein Binding/Elimination/Clearance

Answer 12

Protein Binding: 12%**
Elimination:
Clearance: 12-17 ml/kg/min

Question 13

Precedex

Protein Binding/Elimination/Clearance

Answer 13

Protein Binding: 94%
Elimination:
Clearance: 10-30 ml/kg/min

Question 14

Midazolam

Protein Binding/Elimination/Clearance

Answer 14

Protein Binding: 94%

Elimination: renal excretion of metabolites

Question 15

Sample

Answer 15

Induction:
Infusion:
On:
Dur:

Distribution:
0.5 Life:

Protein Binding:
Elimination:
Clearance:

Question 16

Benzo Duration depends on factor

Answer 16

Hepatic Clearance, shorten time

Question 17

Lorazepam Dosing, Onset, Half Life

Answer 17

PO/IV/IM 1 to 4mg

Onset; half life
PO 30 to 60, 60 to 360
IM 15 to 30, 90 to 120
IV 1 to 5 min, 15 to 20

Question 18

Diazepam Dosing, Onset, Peak

Answer 18

Dosing
Iv/po/I’m 2 to 10 mg

Onset; peak
PO 20 to 40, 60 to 120
IM 10 to 20, 30 to 90
IV 1 to 5, 15 to 30