MISC Pharmacokinetics

Question 1

Total Body weight Meds

Answer 1

Succinylcholine Propofol Infusion

Question 2

Ideal Body Weight Meds and Defined

Answer 2

Based on Height only Altracurium, Nimbex, Rocuonium, Vecuronium

Question 3

Lean Body Weight and Defined

Answer 3

Based on weight + height Propofol Bolus and Opioids

Question 4

Reglan MOA, AE,

Answer 4

Central D antag, ( also Peripheral Cholin Agon) -> promote gastric emptying and increase LES sphincter tone; May cause extrapyramidal/parkinsonian, Rapid motility should not be used in SBO

Question 5

Reglan Onset

Answer 5

15=30 min

Question 6

Zofran MC AE

Answer 6

H.A (11%); QTC widening (20%);

Question 7

Zofran MOA

Answer 7

5-HT3 Antag, @ Chemoreceptor trigger zone at base of fourth ventricle

Question 8

onset of H2 blockers and duration

Answer 8

1hr, cimetidine only 3 to 4. ranitidine, famotidine last for 10 hr. cimetidine is 30 min onset

Question 9

Potassium Sparing Diuretic and MOA [4]

Answer 9

Amiloride, Triamterene, Spironolactone, EPlerenone. blocks na reabosprtion in collecting tubule

Question 10

Acetazolamide effect on P, Na, K, pH

Answer 10

Hyperchoremic, Metabolic Acidosis, Dec K, dec Na (inc Excret), Dec P (inc excret)

Question 11

effect of propofol on hepatic encephalopahty

Answer 11

propofol minimally affect hepatic blood/oxygenation, does not lead to hepatic encephalopathy

Question 12

effect of most sedatives/hypnotic on liver dz

Answer 12

decrease liver blood flow leading to increased accumulation of toxic metabolites (e.g high dose precedex, versed can also hide or worsen encephalopathy)

Question 13

Drug Inducing Hyperkalemia

Answer 13

Question 14

Liothyronine Comments

Answer 14

Most pontent Thyroid Home but can cause MI.

Question 15

Meds Causing HyperCa [4]

Answer 15

Thiazide, Lithium, Theophyilline, Vit A

Question 16

Decadron Anti-Inflammatory Mechnism

Answer 16

Agonist to Nuclear Receptor NR3C1/GCR; Also inhibit prostaglandin synthesis at phospholipase A2 (similar effect as NSAID)

Question 17

Radioactive Iodine Idications and AE

Answer 17

Severely Restrict/destroy Thyroid gland; AE: initial period of increased hyperhyroid symptoms, contraindicated in breast feed/preggers

Question 18

Pramlintide MOA and AE

Answer 18

Amylin Analog -> reduce glcagon release, slows gastric emptying. AE: Hypoglycemia, N/V, worsen of gastroparesis

Question 19

Sitagliptin MOA, and AE

Answer 19

DPP-4 Inhib, may be continued throughout perioperative period

Question 20

Exentaide

Answer 20

GLP-1 analog, delays gastric emptying, reduce food intake, nausea. metabolism through renal fxn

Question 21

Gabapentin MOA

Answer 21

Ca Channel A2Delta

Question 22

Ethosuximide MOA and use and AE

Answer 22

Absent Sz and T-type Ca Channels ; thrombocytopenia,

Question 23

Topiramate MOA

Answer 23

High AG MA

Question 24

TCA MOA and AE MOA

Answer 24

Inhibit presynaptic NT uptake; NE and 5HT and antimuscarinic also affects fast sodium in his-purkinjie -> QRS widening, BBB, PVCs